These studies are directed at clarification of factors that regulate cerebral blood flow and flow through aortic vasa vasorum. Specific goals this year were 1) to determine whether cutting sympathetic nerves to cerebral vessels produces stroke in hypertensive rats; 2) to determine whether stimulation or interruption of cholinergic pathways to cerebral vessels alters regulation of cerebral blood flow; 3) to determine whether increases in intracranial pressure produce redistribution of cerebral blood flow and whether sympathetic nerves contribute to this effect. The most significant achievement this year was the finding that sympathetic denervation predisposes to stroke in the presence of chronic hypertension is an important step in clarification of the physiological role of neural control in the cerebral circulation. This observation may be of importance to physicians who provide care to patients with hypertension and in prevention of stroke. Research goals for the coming year are to answer these questions: 1) Does sympathetic stimulation produce a shift in segmental resistance of cerebral resistance vessels by constricting large arteries but dilating small vessels? 2) Does physiological activation of sympathetic pathways affect cerebral blood flow? 3) Is the greater superficial petrosal nerve the primary source of cholinergic innervation of cerebral vessels?
| Grassi, Guido; Heistad, Donald D (2009) Remodelling of small cerebral arteries in human hypertension: structural and functional alterations. J Hypertens 27:709-11 |
| Heistad, D D; Watanabe, Y; Chu, Y (2008) Gene transfer after subarachnoid hemorrhage: a tool and potential therapy. Acta Neurochir Suppl 104:157-9 |
| Lund, Donald D; Chu, Yi; Brooks, Robert M et al. (2007) Effects of a common human gene variant of extracellular superoxide dismutase on endothelial function after endotoxin in mice. J Physiol 584:583-90 |
| Kitayama, Jiro; Faraci, Frank M; Lentz, Steven R et al. (2007) Cerebral vascular dysfunction during hypercholesterolemia. Stroke 38:2136-41 |
| Chu, Yi; Miller, Jordan D; Heistad, Donald D (2007) Gene therapy for stroke: 2006 overview. Curr Hypertens Rep 9:19-24 |
| Weiss, Robert M; Ohashi, Masuo; Miller, Jordan D et al. (2006) Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 114:2065-9 |
| Chu, Yi; Piper, Robert; Richardson, Simon et al. (2006) Endocytosis of extracellular superoxide dismutase into endothelial cells: role of the heparin-binding domain. Arterioscler Thromb Vasc Biol 26:1985-90 |
| Heistad, Donald D (2006) Gene therapy for vascular disease. Vascul Pharmacol 45:331-3 |
| Sethi, Sanjeev; Iida, Shinichiro; Sigmund, Curt D et al. (2006) Renal thrombotic microangiopathy in a genetic model of hypertension in mice. Exp Biol Med (Maywood) 231:196-203 |
| Kitayama, Jiro; Yi, Chu; Faraci, Frank M et al. (2006) Modulation of dilator responses of cerebral arterioles by extracellular superoxide dismutase. Stroke 37:2802-6 |
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