Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019278-25
Application #
6182865
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1976-09-01
Project End
2001-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
25
Fiscal Year
2000
Total Cost
$454,830
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Mancini, Donna; Monteagudo, Juan; Suárez-Fariñas, Mayte et al. (2018) New methodologies to accurately assess circulating active transforming growth factor-?1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res 192:15-29
Zafar, Hina; Shang, Yi; Li, Jihong et al. (2017) ?IIb?3 binding to a fibrinogen fragment lacking the ?-chain dodecapeptide is activation dependent and EDTA inducible. Blood Adv 1:417-428
Wang, Wei; Burg, Nathalie; Vootukuri, Spandana et al. (2016) Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: Evidence of systemic activation of platelet-derived TGF-?1 and correlation with cardiac dysfunction. Blood Cells Mol Dis 58:1-5
Buitrago, Lorena; Rendon, Augusto; Liang, Yupu et al. (2015) ?IIb?3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia. Proc Natl Acad Sci U S A 112:E1898-907
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Coller, B S (2015) ?IIb?3: structure and function. J Thromb Haemost 13 Suppl 1:S17-25
Coller, Barry S (2014) The platelet: life on the razor's edge between hemorrhage and thrombosis. Transfusion 54:2137-46
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Li, Jihong; Vootukuri, Spandana; Shang, Yi et al. (2014) RUC-4: a novel ?IIb?3 antagonist for prehospital therapy of myocardial infarction. Arterioscler Thromb Vasc Biol 34:2321-9
Provasi, Davide; Negri, Ana; Coller, Barry S et al. (2014) Talin-driven inside-out activation mechanism of platelet ?IIb?3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations. Proteins 82:3231-3240

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