Abstract

The extrathoracic airways influence breathing a great deal, but their physiology has been neglected until fairly recently. The purpose of this project has been to explore and define the influence of the upper airways on the control of breathing. Both sensory and motor mechanisms have been examined, and substantial progress has been made. This application seeks continuing support for this project, to enable us to study three major problems: (1) the inhibition of breathing by physiologically relevant concentrations of CO2 in the laryngeal airway, (2) the modulating influence of vagal afferents on respiratory reflexes from the larynx and elsewhere, and (3) the complex interactions of pressure, flow, resistance, muscle activities and airway calibre in the pharyngeal and nasal segments of the respiratory tract. The proposed studies are based on observations made during the current funding period. We believe these studies will advance substantially the understanding of upper airway physiology and thus ultimately contribute to improving the diagnosis and management of clinical disorders of the respiratory system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019827-16
Application #
3335978
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1979-12-01
Project End
1995-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Bartlett Jr, D; Knuth, S L (2003) Influence of hypercapnia and hypocapnia on bladder contractions and their respiratory consequences. Respir Physiol Neurobiol 134:247-53
Denton, J S; Leiter, J C (2002) Anomalous effects of external TEA on permeation and gating of the A-type potassium current in H. aspersa neuronal somata. J Membr Biol 190:17-28
Stella, M H; Knuth, S L; Bartlett Jr, D (2002) Respiratory response to mechanical stimulation of the gallbladder. Respir Physiol Neurobiol 130:285-92
BuSha, Brett F; Stella, Martha H; Manning, Harold L et al. (2002) Termination of inspiration by phase-dependent respiratory vagal feedback in awake normal humans. J Appl Physiol 93:903-10
Stella, M H; Knuth, S L; Bartlett, D (2001) Respiratory response to baroreceptor stimulation and spontaneous contractions of the urinary bladder. Respir Physiol 124:169-78
Simon, P M; Habel, A M; Daubenspeck, J A et al. (2000) Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans. J Appl Physiol 89:760-9
Stella, M H; Knuth, S L; Bartlett Jr, D (2000) Respiratory response to spontaneous contractions of the urinary bladder in awake and decerebrate rats. Respir Physiol 120:105-14
Terndrup, T E; Darnall, R; Knuth, S L et al. (1999) Effects of experimental cortical seizures on respiratory motor nerve activities in piglets. J Appl Physiol 86:2052-8
Akay, M; Daubenspeck, J A (1999) Investigating the contamination of electroencephalograms by facial muscle electromyographic activity using matching pursuit. Brain Lang 66:184-200
Gdovin, M J; Knuth, S L; Bartlett Jr, D (1997) Roles of the pontine pneumotaxic and micturition centers in respiratory inhibition during bladder contractions. Respir Physiol 107:15-25

Showing the most recent 10 out of 54 publications