Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL020092-08S1
Application #
3336021
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1976-12-01
Project End
1985-11-30
Budget Start
1983-12-01
Budget End
1985-11-30
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Bach, T L; Barsigian, C; Chalupowicz, D G et al. (1998) VE-Cadherin mediates endothelial cell capillary tube formation in fibrin and collagen gels. Exp Cell Res 238:324-34
Bach, T L; Barsigian, C; Yaen, C H et al. (1998) Endothelial cell VE-cadherin functions as a receptor for the beta15-42 sequence of fibrin. J Biol Chem 273:30719-28
Chowdhury, Z A; Barsigian, C; Chalupowicz, G D et al. (1997) Colocalization of tissue transglutaminase and stress fibers in human vascular smooth muscle cells and human umbilical vein endothelial cells. Exp Cell Res 231:38-49
Chalupowicz, D G; Chowdhury, Z A; Bach, T L et al. (1995) Fibrin II induces endothelial cell capillary tube formation. J Cell Biol 130:207-15
Martinez, J; Chalupowicz, D G; Roush, R K et al. (1994) Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers. Biochemistry 33:2538-45
Martinez-Hernandez, A; Martinez, J (1991) The role of capillarization in hepatic failure: studies in carbon tetrachloride-induced cirrhosis. Hepatology 14:864-74
Barsigian, C; Stern, A M; Martinez, J (1991) Tissue (type II) transglutaminase covalently incorporates itself, fibrinogen, or fibronectin into high molecular weight complexes on the extracellular surface of isolated hepatocytes. Use of 2-[(2-oxopropyl)thio] imidazolium derivatives as cellular transg J Biol Chem 266:22501-9
Barsigian, C; Martinez, J (1990) Binding and covalent processing of fibrinogen by hepatocytes and endothelial cells. Blood Coagul Fibrinolysis 1:551-5
Martinez, J; Rich, E; Barsigian, C (1989) Transglutaminase-mediated cross-linking of fibrinogen by human umbilical vein endothelial cells. J Biol Chem 264:20502-8
Barsigian, C; Fellin, F M; Jain, A et al. (1988) Dissociation of fibrinogen and fibronectin binding from transglutaminase-mediated cross-linking at the hepatocyte surface. J Biol Chem 263:14015-22

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