The general aim of this revised competing continuation application is to address, in a timely and effective way, important unanswered questions in cardiovascular epidemiology employing data and analyses from four large Chicago population cohorts. The application focuses on six Specific Aims, and these foci are as follow: a) factors influencing CHD-CVD risk long-term in young adult women and men (ages 18-39 at baseline); b) factors influencing CHD-CVD risk long-term in African-American women and men; c) factors influencing CHD-CVD risk during both earlier and later follow-up (first 15 years and beyond 15 years of follow-up); d) impact of baseline low risk status on long-term risk of mortality from CHD, CVD, non-CVD, and all causes; e) relationship of habitual intake of multiple food groups to 10-year change in serum cholesterol, blood pressure, weight, and to 30-year risks of death from CHD, CVD, cancers, and all causes; f) differences in risk factors impact between groups based on sex, race, age or risk factor status. Questions that are addressed in this application remain unanswered primarily because of the following issues with most other cohort studies. 1) Other cohort studies have not included large numbers of young adult women and men (ages 18-39 with long enough follow-up to accrue substantial numbers of deaths from CHD, CVD or all causes. 2) Other cohort studies have not included substantial numbers of young (ages 18-39) and middle-aged (ages 40-59) African-American women and men to enable detailed study of risk factors and their relations to CHD, CVD and total mortality in this important subgroup of Americans. 3) Other cohort studies have not included participants with markedly differing baseline ages to permit comparisons of risk factor relations in persons of different ages. 4) Other cohort studies have not had samples of women and men large enough, or durations long enough, to assess long-term impact for both genders of low risk status, determined at baseline ages 18-39 and 40-59. 5) Other cohort studies have not included detailed baseline assessment of food and nutrient intakes, combined with repeat risk factor measurements and determination of cause-specific mortality in long-term follow-up. In addition to the unique and important questions- related to current public policy concerns- that this research will address, and the critical characteristics of the four large Chicago cohorts under study for over 25 years, the investigators note that the research team is knowledgeable and experienced and has been engaged together for years in the productive conduct of similar and related research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL021010-22
Application #
6030488
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1977-09-30
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Yano, Yuichiro; Stamler, Jeremiah; Garside, Daniel B et al. (2015) Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study. J Am Coll Cardiol 65:327-335
Goldberger, Jeffrey J; Johnson, Nils P; Subacius, Haris et al. (2014) Comparison of the physiologic and prognostic implications of the heart rate versus the RR interval. Heart Rhythm 11:1925-33
Kizilbash, Mohammad Ali; Daviglus, Martha L; Dyer, Alan R et al. (2008) Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry. Prev Cardiol 11:141-7
Carnethon, Mercedes R; Yan, Lijing; Greenland, Philip et al. (2008) Resting heart rate in middle age and diabetes development in older age. Diabetes Care 31:335-9
Berry, Jarett D; Dyer, Alan; Carnethon, Mercedes et al. (2008) Association of traditional risk factors with cardiovascular death across 0 to 10, 10 to 20, and >20 years follow-up in men and women. Am J Cardiol 101:89-94
Berry, Jarett D; Lloyd-Jones, Donald M; Garside, Daniel B et al. (2007) Framingham risk score and prediction of coronary heart disease death in young men. Am Heart J 154:80-6
Berry, Jarett D; Lloyd-Jones, Donald M; Garside, Daniel B et al. (2007) Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study. Ann Epidemiol 17:591-6
Lloyd-Jones, Donald M; Dyer, Alan R; Wang, Renwei et al. (2007) Risk factor burden in middle age and lifetime risks for cardiovascular and non-cardiovascular death (Chicago Heart Association Detection Project in Industry). Am J Cardiol 99:535-40
Mosley 2nd, William J; Greenland, Philip; Garside, Daniel B et al. (2007) Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes. Hypertension 49:1256-64
Chiu, Brian C-H; Gapstur, Susan M; Greenland, Philip et al. (2006) Body mass index, abnormal glucose metabolism, and mortality from hematopoietic cancer. Cancer Epidemiol Biomarkers Prev 15:2348-54

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