Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL026257-16
Application #
2215975
Study Section
Pathology A Study Section (PTHA)
Project Start
1980-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Kuroki, M; O'Flaherty, J T (1997) Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors. Biochem Biophys Res Commun 232:474-7
O'Flaherty, J T; Kuroki, M; Nixon, A B et al. (1996) 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. J Biol Chem 271:17821-8
O'Flaherty, J T; Kuroki, M; Nixon, A B et al. (1996) 5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes. J Immunol 157:336-42
Sozzani, S; Zhou, D; Locati, M et al. (1996) Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. J Immunol 157:4664-71
Wijkander, J; O'Flaherty, J T; Nixon, A B et al. (1995) 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. J Biol Chem 270:26543-9
O'Flaherty, J T; Tessner, T; Greene, D et al. (1994) Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. Biochim Biophys Acta 1210:209-16
O'Flaherty, J T; Rossi, A G (1993) 5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism. J Biol Chem 268:14708-14
O'Flaherty, J T; Cordes, J; Redman, J et al. (1993) 5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus. Biochem Biophys Res Commun 192:129-34
O'Flaherty, J T; Jacobson, D P; Redman, J F (1992) Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. Biochem J 288 ( Pt 1):241-8
O'Flaherty, J T; Rossi, A G; Redman, J F et al. (1991) Tumor necrosis factor-alpha regulates expression of receptors for formyl-methionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils. J Immunol 147:3842-7

Showing the most recent 10 out of 38 publications