Abstract

The objective of this proposal is to develop criteria to aid in the appropriate selection of patients with chronic aortic and/or mitral regurgitation for valve replacement. Criteria will be based on non-invasive determinations of left and right ventricular myocardial function, made with radionuclide cineaniography at rest and during exercise, and echocardiography at rest, so that results will be easily applicable for repeated periodic assessments in patients not considered to be candidates for catheterization and operation on the basis of current clinical criteria. The study will focus on 1) determination of objective pre-operative predictors of post-operative clinical and myocardial functional results in patients who undergo valve replacement, and 2) determination of objective predictors of future development of symptoms and of irreversible myocardial dysfunction in patients not yet considered to be operative candidates by currently accepted criteria. In addition to assessment of systolic contractile function, the study will utilize invasive and non-invasive methods to determine the prognostic importance of left ventricular diastolic properties assessed prior to operation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL026504-05
Application #
3338640
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1980-12-01
Project End
1987-03-31
Budget Start
1984-12-01
Budget End
1987-03-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Borer, Jeffrey S; Sharma, Abhishek (2015) Drug Therapy for Heart Valve Diseases. Circulation 132:1038-45
Borer, Jeffrey S (2013) Mitral regurgitation: has another magic bullet bitten the dust? Circ Heart Fail 6:624-6
Olafiranye, Oladipupo; Hochreiter, Clare A; Borer, Jeffrey S et al. (2013) Nonischemic mitral regurgitation: prognostic value of nonsustained ventricular tachycardia after mitral valve surgery. Cardiology 124:108-15
Borer, Jeffrey S (2009) Management decisions in aortic regurgitation: has the time for exercise assessment finally arrived? JACC Cardiovasc Imaging 2:56-7
Supino, Phyllis G; Borer, Jeffrey S; Schuleri, Karlheinz et al. (2007) Prognostic value of exercise tolerance testing in asymptomatic chronic nonischemic mitral regurgitation. Am J Cardiol 100:1274-81
Borer, Jeffrey S; Herrold, Edmund McM; Carter, John N et al. (2006) Cellular and molecular basis of remodeling in valvular heart diseases. Heart Fail Clin 2:415-24
Supino, Phyllis G; Borer, Jeffrey S; Herrold, Edmund M et al. (2005) Prognostic impact of systolic hypertension on asymptomatic patients with chronic severe aortic regurgitation and initially normal left ventricular performance at rest. Am J Cardiol 96:964-70
Hochreiter, Clare; Borer, Jeffrey S; Yin, Andrew et al. (2004) Ventricular arrhythmias in mitral regurgitation: frequency, clinical and prognostic importance, management before and after mitral valve surgery. Adv Cardiol 41:108-11
Borer, Jeffrey S; Supino, Phyllis G; Hochreiter, Clare et al. (2004) Valve surgery in the asymptomatic patient with aortic regurgitation: current indications and the effect of change rates in objective measures. Adv Cardiol 41:36-47
Borer, Jeffrey S; Herrold, Edmund McM; Hochreiter, Clare A et al. (2002) Aortic regurgitation: selection of asymptomatic patients for valve surgery. Adv Cardiol 39:74-85

Showing the most recent 10 out of 21 publications