Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL028556-14
Application #
2216311
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1983-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Pharmacology
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Chopra, Nagesh; Kannankeril, Prince J; Yang, Tao et al. (2007) Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ Res 101:617-26
Knollmann, Bjorn C; Chopra, Nagesh; Hlaing, Thinn et al. (2006) Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest 116:2510-20
Kirchhefer, Uwe; Hanske, Gabriela; Jones, Larry R et al. (2006) Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling. Cell Calcium 39:131-42
Kirchhefer, Uwe; Baba, Hideo A; Hanske, Gabriela et al. (2004) Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin. Am J Physiol Heart Circ Physiol 287:H2216-25
Gyorke, Inna; Hester, Nichole; Jones, Larry R et al. (2004) The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J 86:2121-8
Kirchhefer, Uwe; Jones, Larry R; Begrow, Frank et al. (2004) Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovasc Res 62:122-34
Yang, Alexander; Sonin, Dimitry; Jones, Larry et al. (2004) A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy. Am J Physiol Heart Circ Physiol 287:H1096-103
Tijskens, Pierre; Jones, Larry R; Franzini-Armstrong, Clara (2003) Junctin and calsequestrin overexpression in cardiac muscle: the role of junctin and the synthetic and delivery pathways for the two proteins. J Mol Cell Cardiol 35:961-74
Kirchhefer, Uwe; Neumann, Joachim; Bers, Donald M et al. (2003) Impaired relaxation in transgenic mice overexpressing junctin. Cardiovasc Res 59:369-79
Kirchhefer, Uwe; Baba, Hideo A; Kobayashi, Yvonne M et al. (2002) Altered function in atrium of transgenic mice overexpressing triadin 1. Am J Physiol Heart Circ Physiol 283:H1334-43

Showing the most recent 10 out of 56 publications