Our multidisciplinary research group (Department of Physics, Electrical Engineering, Medicine Pathology) will continue to apply our pulmonary NMR techniques to the development of new pulmonary methods for physiologic and clinical exploration of pulmonary and cardiac questions. We will continue our investigations in normal lungs and in various experimental models of pulmonary edema, using excised unperfused lungs and living animals (rats and rabbits) We will: 1) develop and test NMR techniques for measuring lung water, its spatial and density distribution, and its behavior relative to the air/tissue interface. These studies will include determinations of the lung NMR relaxation times T1 and T2, to test the effects of various physiologic and pathologic factors, including regional lung water distribution, state of water (free water vs water bound to macromolecules), level of lung inflation, and pulmonary edema. 2) Develop and test mathematical (geometric) models for explaining the unique NMR behavior of inflated lung (internal sample-induced inhomogeneous broadening). These models will be applied to the simulation of pulmonary edema, especially of its effects on the alveolar air/tissue interface. We will utilize the tissue morphometric characteristics of lung specimens to calculate the NMR behavior predicted on the basis of our models and compare the predicted behavior with our NMR measurements. The basic research included in this proposal will further our understanding of the NMR behavior of lung and establish the feasibility of the application of our new techniques to clinical problems.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031216-09
Application #
3342291
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1990-12-20
Project End
1993-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Cutillo, Antonio G; Chan, Pei H; Ailion, David C et al. (2002) Characterization of bleomycin lung injury by nuclear magnetic resonance: correlation between NMR relaxation times and lung water and collagen content. Magn Reson Med 47:246-56
Shioya, S; Christman, R; Ailion, D C et al. (2000) In vivo Hahn spin-echo decay (Hahn-T2) observation of regional changes in the time course of oleic acid lung injury. J Magn Reson Imaging 11:215-22
Durney, C H; Cutillo, A G; Ailion, D C (2000) Magnetic resonance behavior of normal and diseased lungs: spherical shell model simulations. J Appl Physiol 88:1155-66
Cutillo, A G; Ailion, D C (1999) Modeling the nuclear magnetic resonance behavior of lung: from electrical engineering to critical care medicine. Bioelectromagnetics Suppl 4:110-9
Cutillo, A G; Chan, P H; Ailion, D C et al. (1998) Effects of endotoxin lung injury on NMR T2 relaxation. Magn Reson Med 39:190-7
Hackmann, A; Ailion, D C; Ganesan, K et al. (1996) Application to rat lung of the extended Rorschach-Hazlewood model of spin-lattice relaxation. J Magn Reson B 110:136-7
Hackmann, A; Ailion, D C; Ganesan, K et al. (1996) Extension of the Rorschach--Hazlewood theoretical model for spin-lattice relaxation in biological systems to low frequencies. J Magn Reson B 110:132-5
Laicher, G; Ailion, D C; Cutillo, A G (1996) Water self-diffusion measurements in excised rat lungs. J Magn Reson B 111:243-53
Christman, R A; Ailion, D C; Case, T A et al. (1996) Comparison of calculated and experimental NMR spectral broadening for lung tissue. Magn Reson Med 35:6-13
Cutillo, A G; Goodrich, K C; Ganesan, K et al. (1995) Lung water measurement by nuclear magnetic resonance: correlation with morphometry. J Appl Physiol 79:2163-8

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