The investigators hypothesize that the cellular responses to local and distant production of TGF-b are set by the expression of specific receptors for the cytokine.
Aim 1 is to determine the temporal and spatial expression of rat lung TGFR during ontogeny.
Aim 2 is to correlate the expression of rat lung TGFR during development with their expression during the repair of perinatal lung injury.
Aim 3 is to test whether TGFRI or TGFRII controls production of ECM components by expressing mutated TGFRI and TGFRII in fibroblasts cultured from lungs of fetal rats.
Aim 4 is to test the role of fibroblast TGFR expression as instruction for lung development.
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