Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL032656-10A1
Application #
2217052
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1984-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Rau, Jill C; Mitchell, Jennifer W; Fortenberry, Yolanda M et al. (2011) Heparin cofactor II: discovery, properties, and role in controlling vascular homeostasis. Semin Thromb Hemost 37:339-48
Gramling, Mark W; Beaulieu, Lea M; Church, Frank C (2010) Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction. Exp Cell Res 316:314-28
Rau, Jill C; Deans, Carolyn; Hoffman, Maureane R et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol 87:178-83
Gonzales, Patrick R; Walston, Timothy D; Camacho, Laureano O et al. (2007) Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition. Biochim Biophys Acta 1774:1431-7
Rau, J C; Beaulieu, L M; Huntington, J A et al. (2007) Serpins in thrombosis, hemostasis and fibrinolysis. J Thromb Haemost 5 Suppl 1:102-15
Fortenberry, Y M; Whinna, H C; Cooper, S T et al. (2007) Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin. J Thromb Haemost 5:1486-92
Beaulieu, Lea M; Church, Frank C (2007) Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1. Exp Cell Res 313:677-87
Whitley, Brandi R; Beaulieu, Lea M; Carter, Jennifer C et al. (2007) Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol Oncol 104:470-9
Beaulieu, L M; Church, F C (2006) Is protein C inhibitor antithrombotic and protective in pulmonary hypertension? J Thromb Haemost 4:2327-30
Glasscock, Laura N; Rehault, Sophie M; Gregory, Christopher W et al. (2005) Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft. Exp Mol Pathol 79:23-32

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