Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034788-07
Application #
3348144
Study Section
Special Emphasis Panel (SSS (J))
Project Start
1985-04-01
Project End
1991-06-30
Budget Start
1991-04-01
Budget End
1991-06-30
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Tsotakos, Nikolaos; Phelps, David S; Yengo, Christopher M et al. (2016) Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging. Biol Sex Differ 7:18
Lopez-Rodriguez, Elena; Pascual, Alicia; Arroyo, Raquel et al. (2016) Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films. Biophys J 111:524-536
Yang, Linlin; Carrillo, Marykate; Wu, Yuchieh M et al. (2015) SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS One 10:e0126576
Tsotakos, Nikolaos; Silveyra, Patricia; Lin, Zhenwu et al. (2015) Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Am J Physiol Lung Cell Mol Physiol 308:L58-75
Noutsios, Georgios T; Ghattas, Paul; Bennett, Stephanie et al. (2015) 14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA. Am J Physiol Lung Cell Mol Physiol 309:L147-57
Quintanilla, Hector D; Liu, Yuying; Fatheree, Nicole Y et al. (2015) Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 60:613-20
Grageda, Melissa; Silveyra, Patricia; Thomas, Neal J et al. (2015) DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. Exp Lung Res 41:93-102
Silveyra, Patricia; Chroneos, Zissis C; DiAngelo, Susan L et al. (2014) Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res 40:354-66
Silveyra, Patricia; DiAngelo, Susan L; Floros, Joanna (2014) An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol 307:L106-19
Phelps, David S; Umstead, Todd M; Floros, Joanna (2014) Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome. J Proteomics 108:427-44

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