The long range objective is to produce a genetically determined model of essential hypertension in the dog for use in drug testing and investigation of the underlying genetic, biochemical, and physiological mechanisms of this disorder.
The specific aim i s to establish a line of hypertensive dogs and characterize the pathophysiologic features of hypertension, comparing this line to comparable controls. A colony of hypertensive dogs exists in our laboratory as a result of breeding two unrelated dogs with severe essential hypertension. A breeding plan is proposed to use F1 backcross matings and then select the dogs with the most consistent arterial hypertension to concentrate the genome in four generations. The criteria for selection include direct blood pressure measurements, opthalmologic examination, response to oral sodium load, and response to a pressor agent. The natural history of the disease will be characterized in the breeding dogs over a period of years. Further characterization of hypertension will be done in collaboration with colleagues at a pharmaceutical firm. After a genetic model has been proven and shown to be useful, collaboration with a commercial breeder is proposed to make hypertensive dogs generally available.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL035435-05
Application #
3349320
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1986-05-01
Project End
1991-04-30
Budget Start
1990-05-01
Budget End
1991-04-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bovee, K C; Littman, M P; Saleh, F et al. (1986) Essential hereditary hypertension in dogs: a new animal model. J Hypertens Suppl 4:S172-1