Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036000-11
Application #
2217978
Study Section
Metabolism Study Section (MET)
Project Start
1985-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Talmud, P J; Hall, S; Holleran, S et al. (1998) LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics. J Lipid Res 39:1189-96
Jiang, H; Ginsberg, H N; Wu, X (1998) Glucose does not stimulate apoprotein B secretion from HepG2 cells because of insufficient stimulation of triglyceride synthesis. J Lipid Res 39:2277-85
Berglund, L; Witztum, J L; Galeano, N F et al. (1998) Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tr J Lipid Res 39:913-24
Fisher, E A; Zhou, M; Mitchell, D M et al. (1997) The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem 272:20427-34
Wu, X; Shang, A; Jiang, H et al. (1997) Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells. Arterioscler Thromb Vasc Biol 17:3347-55
Wu, X; Sakata, N; Lele, K M et al. (1997) A two-site model for ApoB degradation in HepG2 cells. J Biol Chem 272:11575-80
Shachter, N S; Ebara, T; Ramakrishnan, R et al. (1996) Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl. J Clin Invest 98:846-55
Zhou, M; Wu, X; Ginsberg, H N (1996) Evidence that a rapidly turning over protein, normally degraded by proteasomes, regulates hsp72 gene transcription in HepG2 cells. J Biol Chem 271:24769-75
Ginsberg, H N (1996) Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes 45 Suppl 3:S27-30
Wu, X; Shang, A; Jiang, H et al. (1996) Low rates of apoB secretion from HepG2 cells result from reduced delivery of newly synthesized triglyceride to a ""secretion-coupled"" pool. J Lipid Res 37:1198-206

Showing the most recent 10 out of 37 publications