Abstract

This competing renewal examines how blood pressure regulation differs between blacks and whites. There is increasing evidence suggesting that blood pressure decreases (or """"""""dips"""""""") less at nighttime in certain groups of individuals and that such relative non-dipping of blood pressure is related to adverse health outcomes. Data suggest that non-dipping is found more frequently in Blacks. We will study 80 blacks and 80 whites in an effort to understand the psychological and physiological correlates of nocturnal BP dipping. Patients' sleep and ambulatory blood pressure will be studied at home and in the Clinical Research Center environment. Physiological characterization will include 24-hour urinary norepinephrine, beta-adrenergic receptors on lymphocytes, hemodynamic responses to behavioral stressors, heart rate and blood pressure responses to infused isoproterenol. Psychological characterization will include assessment of life stressors and job stress, mood, anger/hostility, and social desirability.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036005-19
Application #
6642220
Study Section
Special Emphasis Panel (ZRG1-RPHB-2 (01))
Program Officer
Jobe, Jared B
Project Start
1985-06-16
Project End
2005-07-31
Budget Start
2003-08-01
Budget End
2005-07-31
Support Year
19
Fiscal Year
2003
Total Cost
$499,376
Indirect Cost

  Institution

Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

von Känel, Roland (2015) ACUTE MENTAL STRESS AND HEMOSTASIS: WHEN PHYSIOLOGY BECOMES VASCULAR HARM. Thromb Res 135:S52-S55
Cooper, Denise C; Ziegler, Michael G; Milic, Milos S et al. (2014) Endothelial function and sleep: associations of flow-mediated dilation with perceived sleep quality and rapid eye movement (REM) sleep. J Sleep Res 23:84-93
Euteneuer, Frank; Mills, Paul J; Pung, Meredith A et al. (2014) Neighborhood problems and nocturnal blood pressure dipping. Health Psychol 33:1366-72
Euteneuer, Frank; Ziegler, Michael G; Mills, Paul J et al. (2014) In vivo ?-adrenergic receptor responsiveness: ethnic differences in the relationship with symptoms of depression and fatigue. Int J Behav Med 21:843-50
Euteneuer, Frank; Mills, Paul J; Rief, Winfried et al. (2012) Association of in vivo ýý-adrenergic receptor sensitivity with inflammatory markers in healthy subjects. Psychosom Med 74:271-7
Tomfohr, Lianne M; Edwards, Kate M; Dimsdale, Joel E (2012) Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Med Rev 16:243-9
Euteneuer, Frank; Mills, Paul J; Rief, Winfried et al. (2012) Subjective social status predicts in vivo responsiveness of ýý-adrenergic receptors. Health Psychol 31:525-9
Cooper, Denise C; Tomfohr, Lianne M; Milic, Milos S et al. (2011) Depressed mood and flow-mediated dilation: a systematic review and meta-analysis. Psychosom Med 73:360-9
Nation, Daniel A; Hong, Suzi; Jak, Amy J et al. (2011) Stress, exercise, and Alzheimer's disease: a neurovascular pathway. Med Hypotheses 76:847-54
Cooper, Denise C; Milic, Milos S; Mills, Paul J et al. (2010) Endothelial function: the impact of objective and subjective socioeconomic status on flow-mediated dilation. Ann Behav Med 39:222-31

Showing the most recent 10 out of 27 publications