Abstract

The focus of the work in this investigator's laboratory is to determine the mechanisms of activation by a variety of locally active chemicals of somatic and visceral afferent fibers involved in reflex cardiovascular regulation during muscle contraction and visceral ischemia.
The first aim i nvestigates serotonin and histamine involvement in the interstitial lymph during visceral ischemia.
The second aim looks at the muscle mechanosensitive nerve fibers in mesenteric ischemia.
The third aim addresses the hypothesis that increased bradykinin release resulting from excess lactic acid leads to the formation of prostaglandins and leukotrienes. The overall result accounts for the reflex cardiovascular changes observed during visceral ischemia. Finally, the role of reactive oxygen species on the reflex and the differences in chemical and mechanical stimuli during sinusoidal versus static muscle contraction will be investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036527-17
Application #
6151278
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1999-02-12
Project End
2003-01-31
Budget Start
2000-02-01
Budget End
2003-01-31
Support Year
17
Fiscal Year
2000
Total Cost
$288,571
Indirect Cost

  Institution

Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Li, Peng; Longhurst, John C (2010) Neural mechanism of electroacupuncture's hypotensive effects. Auton Neurosci 157:24-30
Tjen-A-Looi, Stephanie C; Li, Peng; Longhurst, John C (2004) Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints. Am J Physiol Regul Integr Comp Physiol 287:R852-62
Guo, Zhi-Ling; Moazzami, Ali R; Longhurst, John C (2004) Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons. Brain Res 1030:103-15
Tjen-A-Looi, Stephanie C; Li, Peng; Longhurst, John C (2003) Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats. Auton Neurosci 106:119-31
Guo, Zhi-Ling; Lai, Hui-Chin; Longhurst, John C (2002) Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. Brain Res 925:55-66
Li, Peng; Rowshan, Kasra; Crisostomo, Melissa et al. (2002) Effect of electroacupuncture on pressor reflex during gastric distension. Am J Physiol Regul Integr Comp Physiol 283:R1335-45
Fu, Liang-Wu; Longhurst, John C (2002) Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats. Am J Physiol Heart Circ Physiol 282:H100-9
Gee, B Y; Tjen-A-Looi, S C; Hill, J M et al. (2002) Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia. Am J Physiol Regul Integr Comp Physiol 282:R850-7
Longhurst, J C; Tjen-A-Looi, S C; Fu, L W (2001) Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes. Ann N Y Acad Sci 940:74-95
Daniels, J W; Stebbins, C L; Longhurst, J C (2000) Hemodynamic responses to static and dynamic muscle contractions at equivalent workloads. Am J Physiol Regul Integr Comp Physiol 279:R1849-55

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