Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL037528-10
Application #
2218497
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-09-30
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Shalev, O; Hileti, D; Nortey, P et al. (1999) Transport of 14C-deferiprone in normal, thalassaemic and sickle red blood cells. Br J Haematol 105:1081-3
Browne, P; Shalev, O; Hebbel, R P (1998) The molecular pathobiology of cell membrane iron: the sickle red cell as a model. Free Radic Biol Med 24:1040-8
Sheng, K; Shariff, M; Hebbel, R P (1998) Comparative oxidation of hemoglobins A and S. Blood 91:3467-70
Cragg, L; Hebbel, R P; Miller, W et al. (1998) The iron chelator L1 potentiates oxidative DNA damage in iron-loaded liver cells. Blood 92:632-8
Shalev, O; Hebbel, R P (1996) Extremely high avidity association of Fe(III) with the sickle red cell membrane. Blood 88:349-52
Shalev, O; Hebbel, R P (1996) Catalysis of soluble hemoglobin oxidation by free iron on sickle red cell membranes. Blood 87:3948-52
Enright, H; Miller, W J; Hays, R et al. (1996) Preferential targeting of oxidative base damage to internucleosomal DNA. Carcinogenesis 17:1175-7
Browne, P V; Mosher, D F; Steinberg, M H et al. (1996) Disturbance of plasma and platelet thrombospondin levels in sickle cell disease. Am J Hematol 51:296-301
Shalev, O; Repka, T; Goldfarb, A et al. (1995) Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo. Blood 86:2008-13
Sugihara, T; Yawata, Y; Hebbel, R P (1994) Deformation of swollen erythrocytes provides a model of sickling-induced leak pathways, including a novel bromide-sensitive component. Blood 83:2684-91

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