Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL038118-09
Application #
2218697
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1986-07-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1999-07-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Connolly, Jeanne M; Alferiev, Ivan; Clark-Gruel, Jocelyn N et al. (2005) Triglycidylamine crosslinking of porcine aortic valve cusps or bovine pericardium results in improved biocompatibility, biomechanics, and calcification resistance: chemical and biological mechanisms. Am J Pathol 166:1-13
Ryan, Kenneth; Russ, Andreas P; Levy, Robert J et al. (2004) Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy. Hum Gene Ther 15:842-55
Connolly, Jeanne M; Alferiev, Ivan; Kronsteiner, Allyson et al. (2004) Ethanol inhibition of porcine bioprosthetic heart valve cusp calcification is enhanced by reduction with sodium borohydride. J Heart Valve Dis 13:487-93
Levy, Robert J; Vyavahare, Narendra; Ogle, Matthew et al. (2003) Inhibition of cusp and aortic wall calcification in ethanol- and aluminum-treated bioprosthetic heart valves in sheep: background, mechanisms, and synergism. J Heart Valve Dis 12:209-16; discussion 216
Jian, Bo; Narula, Navneet; Li, Quan-yi et al. (2003) Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75:457-65; discussion 465-6
Ogle, Matthew F; Kelly, Sheila J; Bianco, Richard W et al. (2003) Calcification resistance with aluminum-ethanol treated porcine aortic valve bioprostheses in juvenile sheep. Ann Thorac Surg 75:1267-73
Jian, Bo; Xu, Jie; Connolly, Jeanne et al. (2002) Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells. Am J Pathol 161:2111-21
Li, Quan-Yi; Jones, Peter L; Lafferty, Robert P et al. (2002) Thymosin beta4 regulation, expression and function in aortic valve interstitial cells. J Heart Valve Dis 11:726-35
Xu, Jie; Jian, Bo; Chu, Richard et al. (2002) Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. Am J Pathol 161:2209-18
Jian, B; Jones, P L; Li, Q et al. (2001) Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis. Am J Pathol 159:321-7

Showing the most recent 10 out of 33 publications