Coronary artery disease is the leading cause of death in the United States. The overall objective of the proposed project is to develop, optimize, and validate a high resolution magnetic resonance (MR) imaging protocol to evaluate coronary artery disease noninvasively. The long-term goal is to provide a noninvasive screening test for coronary artery disease. This test could potentially be combined with other hemodynamic, functional, and metabolic studies available from MRI to form a comprehensive examination of coronary artery disease for improved patient care and cost savings. The specific goal of the project is to be able to image proximal coronary arteries within several breath-holds and with a spatial resolution of 0.5 mm3 using a three-dimensional data acquisition method. For this purpose, fast MR imaging techniques (segmented echo-planar imaging and quarter Fourier reconstruction) will be developed to improve the speed and resolution of coronary artery images. The utility of newly developed intravascular MR contrast agents will be evaluated for coronary artery imaging and the imaging techniques will be optimized for maximal blood signal-to-noise ratio and blood/background contrast-to-noise ratio. Real-time slice-following and retrospective motion correction schemes will be developed to register data acquired from different breath-holds. Rigorous theoretical simulations, phantom studies, normal volunteer studies, and animal studies will be performed to validate each aspect of the imaging protocol. Particularly, the optimized protocol will be tested in a pig model with coronary artery stenosis created by balloon overstretch injury of arteries and atherogenic diet. Finally, the optimized and validated imaging protocol will be used to image patients with coronary artery disease to define its capability to detect coronary artery disease in a real clinical setting in comparison with conventional x-ray angiography. The end point of the project is to have a robust, clinically viable, rigorously validated protocol for imaging the proximal coronary arteries.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL038698-13
Application #
6526701
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Dunn, Rosalie
Project Start
1993-08-01
Project End
2006-08-31
Budget Start
2002-09-01
Budget End
2006-08-31
Support Year
13
Fiscal Year
2002
Total Cost
$312,400
Indirect Cost
Name
Northwestern University at Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Pang, Jianing; Chen, Yuhua; Fan, Zhaoyang et al. (2016) High efficiency coronary MR angiography with nonrigid cardiac motion correction. Magn Reson Med 76:1345-1353
Pang, Jianing; Sharif, Behzad; Arsanjani, Reza et al. (2015) Accelerated whole-heart coronary MRA using motion-corrected sensitivity encoding with three-dimensional projection reconstruction. Magn Reson Med 73:284-91
Nguyen, Christopher; Fan, Zhaoyang; Xie, Yibin et al. (2014) In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 16:68
Pang, Jianing; Sharif, Behzad; Fan, Zhaoyang et al. (2014) ECG and navigator-free four-dimensional whole-heart coronary MRA for simultaneous visualization of cardiac anatomy and function. Magn Reson Med 72:1208-17
Nguyen, Christopher; Fan, Zhaoyang; Sharif, Behzad et al. (2014) In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: a motion compensated diffusion-prepared balanced steady-state free precession approach. Magn Reson Med 72:1257-67
Sharif, Behzad; Dharmakumar, Rohan; Arsanjani, Reza et al. (2014) Non-ECG-gated myocardial perfusion MRI using continuous magnetization-driven radial sampling. Magn Reson Med 72:1620-8
Pang, Jianing; Bhat, Himanshu; Sharif, Behzad et al. (2014) Whole-heart coronary MRA with 100% respiratory gating efficiency: self-navigated three-dimensional retrospective image-based motion correction (TRIM). Magn Reson Med 71:67-74
Sharif, Behzad; Dharmakumar, Rohan; LaBounty, Troy et al. (2014) Towards elimination of the dark-rim artifact in first-pass myocardial perfusion MRI: removing Gibbs ringing effects using optimized radial imaging. Magn Reson Med 72:124-36
He, Yi; Zhang, Zhaoqi; Dai, Qinyi et al. (2012) Accuracy of MRI to identify the coronary artery plaque: a comparative study with intravascular ultrasound. J Magn Reson Imaging 35:72-8
Yang, Qi; Li, Kuncheng; Liu, Xin et al. (2012) 3.0T whole-heart coronary magnetic resonance angiography performed with 32-channel cardiac coils: a single-center experience. Circ Cardiovasc Imaging 5:573-9

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