Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL039703-06S1
Application #
3356549
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1988-03-01
Project End
1997-02-28
Budget Start
1993-03-01
Budget End
1994-02-28
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Tabas, I (1999) Secretory sphingomyelinase. Chem Phys Lipids 102:123-30
Marathe, S; Schissel, S L; Yellin, M J et al. (1998) Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling. J Biol Chem 273:4081-8
Schissel, S L; Keesler, G A; Schuchman, E H et al. (1998) The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J Biol Chem 273:18250-9
Zha, X; Pierini, L M; Leopold, P L et al. (1998) Sphingomyelinase treatment induces ATP-independent endocytosis. J Cell Biol 140:39-47
Tabas, I (1997) Phospholipid metabolism in cholesterol-loaded macrophages. Curr Opin Lipidol 8:263-7
Zha, X; Tabas, I; Leopold, P L et al. (1997) Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arterioscler Thromb Vasc Biol 17:1421-31
Skiba, P J; Zha, X; Maxfield, F R et al. (1996) The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent. J Biol Chem 271:13392-400
Schissel, S L; Schuchman, E H; Williams, K J et al. (1996) Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem 271:18431-6
Schissel, S L; Tweedie-Hardman, J; Rapp, J H et al. (1996) Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Invest 98:1455-64
Tabas, I; Marathe, S; Keesler, G A et al. (1996) Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam c J Biol Chem 271:22773-81

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