Individuals with HIV-1 infection experience frequent bacterial pulmonary infections, even early in the course of their disease. This investigator is studying the molecular event involved in the processing and secretion of interleukin 1 beta from human monocytes and alveolar macrophages. Interleukin 1 beta has an important role in sepsis induced shock and pulmonary tissue injury. Interleukin 1b can promote and maintain inflammation via its potent effects on many tissues. For example IL-1b induces vascular endothelium to display integrins, triggers neutrophils to activation and migration, signals mesenchymal cells to proliferate and initiates a secondary cascade of cytokines such as IL-6 and IL-8. Thus IL-1b proximally controls may subsequent inflammatory events.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040871-10
Application #
2771277
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1989-07-01
Project End
2001-12-31
Budget Start
1998-09-01
Budget End
2001-12-31
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
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