Evaluating the function of the heart is an important part of diagnosing and treating patients with heart disease, the leading cause of death and disability in the Western World. However, conventional means of assessing cardiac function have many limitations. Even invasive methods used for research purposes are limited to evaluation of only a limited portion of the heart wall; they also may themselves alter the motion of the portion of the heart being studied. The right ventricle (RV) is even more difficult to study than the left (LV). Magnetic resonance imaging (MRI), used with noninvasive tissue tagging with spatial modulation of magnetization (SPAMM), provides a new method of quantitatively studying the detailed motion patterns within the heart wall. In previous research, MRI methods have been developed for using SPAMM to study the heart, along with methods to analyze the resulting tagged images, which have been incorporated in an integrated program, SPAMMVU. This has made it possible to begin studying the effects of a number of heart diseases on cardiac function, in significantly more detail than was previously possible. However, more basic work needs to be done, both to more fully exploit the capabilities of SPAMM-tagged MRI to study the full 3-dimensional motion of the ventricles and to make these methods more practical for clinical application. In this application, it is specifically proposed: 1) to further develop the capabilities of SPAMM-tagged MRI and SPAMMVU to study the full 3D motion of both the LV and RV, 2) to make the use of these methods more clinically relevant, and 3) to use SPAMM to study a series of patients with RV disease, as a preliminary evaluation of the clinical capabilities of SPAMM methods. Accomplishment of these aims will provide a new tool for cardiac function evaluation.for both research and clinical applications, and should lead to both a better understanding of normal and abnormal heart function and a more sensitive and accurate means for guiding the clinical management of individual patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL043014-11
Application #
6351465
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Altieri, Frank
Project Start
1990-04-01
Project End
2004-01-31
Budget Start
2001-02-27
Budget End
2002-01-31
Support Year
11
Fiscal Year
2001
Total Cost
$323,970
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Axel, Leon; Montillo, Albert; Kim, Daniel (2005) Tagged magnetic resonance imaging of the heart: a survey. Med Image Anal 9:376-93
Moses, Daniel A; Axel, Leon (2004) Quantification of the curvature and shape of the interventricular septum. Magn Reson Med 52:154-63
Yeon, S B; Reichek, N; Tallant, B A et al. (2001) Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry. J Am Coll Cardiol 38:555-61
Yuan, Q; Axel, L; Hernandez, E H et al. (2000) Cardiac-respiratory gating method for magnetic resonance imaging of the heart. Magn Reson Med 43:314-8
Haber, I; Metaxas, D N; Axel, L (2000) Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI. Med Image Anal 4:335-55
Fayad, Z A; Ferrari, V A; Kraitchman, D L et al. (1998) Right ventricular regional function using MR tagging: normals versus chronic pulmonary hypertension. Magn Reson Med 39:116-23
Kraitchman, D L; Young, A A; Bloomgarden, D C et al. (1998) Integrated MRI assessment of regional function and perfusion in canine myocardial infarction. Magn Reson Med 40:311-26
Axel, L (1997) Noninvasive measurement of cardiac strain with MRI. Adv Exp Med Biol 430:249-56
Gai, N; Axel, L (1997) A dual approach to linogram imaging for MRI. Magn Reson Med 38:337-41
Bloomgarden, D C; Fayad, Z A; Ferrari, V A et al. (1997) Global cardiac function using fast breath-hold MRI: validation of new acquisition and analysis techniques. Magn Reson Med 37:683-92

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