Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL043617-04S1
Application #
3362316
Study Section
Special Emphasis Panel (SRC (EA))
Project Start
1989-07-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Moreno-Ulloa, Aldo; Nogueira, Leonardo; Rodriguez, Alonso et al. (2015) Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci 70:1370-8
DeCoux, Ashley; Lindsey, Merry L; Villarreal, Francisco et al. (2014) Myocardial matrix metalloproteinase-2: inside out and upside down. J Mol Cell Cardiol 77:64-72
Ortiz-Vilchis, Pilar; Yamazaki, Katrina Go; Rubio-Gayosso, Ivan et al. (2014) Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling. Eur J Pharmacol 744:76-82
Spinale, Francis G; Villarreal, Francisco (2014) Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors. Biochem Pharmacol 90:7-15
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Gutierrez-Salmean, Gabriela; Ciaraldi, Theodore P; Nogueira, Leonardo et al. (2014) Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem 25:91-4
Aguilar, Hugo; Fricovsky, Eduardo; Ihm, Sang et al. (2014) Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis. Am J Physiol Cell Physiol 306:C794-804
Moreno-Ulloa, Aldo; Romero-Perez, Diego; Villarreal, Francisco et al. (2014) Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. Bioorg Med Chem Lett 24:2749-52
Yamazaki, Katrina Go; Andreyev, Aleksander Y; Ortiz-Vilchis, Pilar et al. (2014) Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol 175:297-306
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