Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL043707-07
Application #
2221140
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1990-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

El Osta, Mohamad; Liu, Mengling; Adada, Mohamad et al. (2014) Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J 28:495-505
Liu, Mengling; Idkowiak-Baldys, Jolanta; Roddy, Patrick L et al. (2013) Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One 8:e80721
Jenkins, Russell W; Idkowiak-Baldys, Jolanta; Simbari, Fabio et al. (2011) A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. J Biol Chem 286:3777-88
El-Osta, Mohamad A; Idkowiak-Baldys, Jola; Hannun, Yusuf A (2011) Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem 286:19340-53
Idkowiak-Baldys, Jolanta; Baldys, Aleksander; Raymond, John R et al. (2009) Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem 284:22322-31
Kitatani, Kazuyuki; Idkowiak-Baldys, Jolanta; Hannun, Yusuf A (2007) Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem 282:20647-56
Idkowiak-Baldys, Jolanta; Becker, Kevin P; Kitatani, Kazuyuki et al. (2006) Dynamic sequestration of the recycling compartment by classical protein kinase C. J Biol Chem 281:22321-31
Taha, Tarek Assad; Hannun, Yusuf Awni; Obeid, Lina Marie (2006) Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol 39:113-31
Becker, K P; Hannun, Y A (2005) Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci 62:1448-61
Becker, Kevin P; Kitatani, Kazuyuki; Idkowiak-Baldys, Jolanta et al. (2005) Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem 280:2606-12

Showing the most recent 10 out of 45 publications