Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL045635-07A1
Application #
2222316
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1991-12-02
Project End
2001-05-31
Budget Start
1996-07-05
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Bagaitkar, Juhi; Huang, Jing; Zeng, Melody Yue et al. (2018) NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood 131:2367-2378
Roos, Dirk; van Buul, Jaap D; Tool, Anton Tj et al. (2014) Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67(phox). J Clin Cell Immunol 5:
Zeng, Melody Yue; Pham, Duy; Bagaitkar, Juhi et al. (2013) An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood 121:3473-83
Crotzer, Victoria L; Matute, Juan D; Arias, Andrés A et al. (2012) Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol 189:3800-4
Casbon, Amy-Jo; Long, Matthew E; Dunn, Kenneth W et al. (2012) Effects of IFN-? on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. J Leukoc Biol 92:869-82
Jacob, Chaim O; Eisenstein, Miriam; Dinauer, Mary C et al. (2012) Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A 109:E59-67
Bagaitkar, Juhi; Matute, Juan D; Austin, Anthony et al. (2012) Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice. Blood 120:3385-7
Yamada, Mitsuhiro; Gomez, John C; Chugh, Pauline E et al. (2011) Interferon-? production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med 183:1391-401
Bustamante, Jacinta; Arias, Andres A; Vogt, Guillaume et al. (2011) Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol 12:213-21
Li, Xing Jun; Marchal, Christophe C; Stull, Natalie D et al. (2010) p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem 285:35169-79

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