Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL045742-07A1
Application #
2222461
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1991-01-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Physiology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Bohnen, Michael S; Ma, Lijiang; Zhu, Na et al. (2018) Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension. Circ Genom Precis Med 11:e002087
Cooper, Paige E; McClenaghan, Conor; Chen, Xingyu et al. (2017) Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. J Biol Chem 292:17387-17398
Kirk, Edwin P; Scurr, Ingrid; van Haaften, Gijs et al. (2017) Clinical utility gene card for: CantĂș syndrome. Eur J Hum Genet 25:
Nichols, Colin G (2016) Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Card Electrophysiol Clin 8:323-35
Levin, Mark D; Singh, Gautam K; Zhang, Hai Xia et al. (2016) K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A 113:6773-8
Kharade, Sujay V; Nichols, Colin; Denton, Jerod S (2016) The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics. Future Med Chem 8:789-802
Levin, Mark D; Zhang, Haixia; Uchida, Keita et al. (2015) Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome. Heart Rhythm 12:2316-24
Nelson, Peter T; Jicha, Gregory A; Wang, Wang-Xia et al. (2015) ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Res Rev 24:111-25
Cooper, Paige E; Reutter, Heiko; Woelfle, Joachim et al. (2014) CantĂș syndrome resulting from activating mutation in the KCNJ8 gene. Hum Mutat 35:809-13
Nichols, Colin G; Singh, Gautam K; Grange, Dorothy K (2013) KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res 112:1059-72

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