Our goal in this project is to substantially improve the ability of magnetic resonance imaging (MRI) and angiography (MRA) to provide an unambiguous evaluation of the intracranial vasculature. This is a continuation of our long term objective to improve MRI/MRA to provide diagnostic information competitive to X-ray angiography in a manner that is safer and less expensive. Based upon the work of this and other projects, currently available MRA techniques have replaced many diagnostic X-ray angiography procedures. During the prior funding period (years 7 to 10), we have implemented several novel techniques to improve white blood and black blood intacranial MRA and have tested these as applied to the detection and management of intracranial aneurysms. Although white blood and black blood MRA have been substantially improved, both techniques have residual artifacts and ambiguities. White blood techniques still remain as the standard of care in most intracranial MRA applications. However, using a single image contrast is contrary to other diagnostic MRI procedures, such as evaluating parenchymal lesions, that typically rely on multiple types of image contrast to ensure accurate discrimination of normal and pathologic tissue. Our principle focus during the next funding period (years 11 to 15) will be to develop a novel composite set of MRI/MRA techniques, optimized on both 1.5T and 3.0T MRI scanners, yielding a set of multiple contrasts that collectively overcome ambiguities inherent in any individual technique. These techniques will provide isotropic high spatial resolution with sufficient signal to noise ratio (SNR). The acquisitions will be coupled with novel image registration, visualization, and analysis tools. The goal of this project is to determine an optimal and efficient combination of image contrasts necessary for an unambiguous evaluation of the intracranial vasculature. The value of these techniques will be assessed via application to a population of unruptured intracranial aneurysms, normal controls and eventually other disorders such as intracranial atherosclerosis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048223-13
Application #
7090763
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Buxton, Denis B
Project Start
1993-01-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
13
Fiscal Year
2006
Total Cost
$297,535
Indirect Cost
Name
University of Utah
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Mendes, Jason; Parker, Dennis L; McNally, Scott et al. (2014) Three-dimensional dynamic contrast enhanced imaging of the carotid artery with direct arterial input function measurement. Magn Reson Med 72:816-22
Hulet, Jordan P; Greiser, Andreas; Mendes, Jason K et al. (2014) Highly accelerated cardiac cine phase-contrast MRI using an undersampled radial acquisition and temporally constrained reconstruction. J Magn Reson Imaging 39:455-62
Mendes, Jason; Parker, Dennis L; Kim, Seong-Eun et al. (2013) Reduced blood flow artifact in intraplaque hemorrhage imaging using CineMPRAGE. Magn Reson Med 69:1276-84
Diedrich, Karl T; Roberts, John A; Schmidt, Richard H et al. (2012) Comparing performance of centerline algorithms for quantitative assessment of brain vascular anatomy. Anat Rec (Hoboken) 295:2179-90
Diedrich, Karl T; Roberts, John A; Schmidt, Richard H et al. (2011) Validation of an arterial tortuosity measure with application to hypertension collection of clinical hypertensive patients. BMC Bioinformatics 12 Suppl 10:S15
Park, J K; Kim, S-E; Trieman, G S et al. (2011) High-resolution diffusion-weighted imaging of neck lymph nodes using 2D-single-shot interleaved multiple inner volume imaging diffusion-weighted echo-planar imaging at 3T. AJNR Am J Neuroradiol 32:1173-7
Kim, Seong-Eun; Treiman, Gerald S; Roberts, John A et al. (2011) In vivo and ex vivo measurements of the mean ADC values of lipid necrotic core and hemorrhage obtained from diffusion weighted imaging in human atherosclerotic plaques. J Magn Reson Imaging 34:1167-75
Minalga, Emilee; Rose, John; Choi, Seong-Eun et al. (2011) A 20-channel coil for improved magnetic resonance imaging of the optic nerve. Concepts Magn Reson Part B Magn Reson Eng 39B:26-36
Diedrich, Karl T; Roberts, John A; Schmidt, Richard H et al. (2011) Medical record and imaging evaluation to identify arterial tortuosity phenotype in populations at risk for intracranial aneurysms. AMIA Annu Symp Proc 2011:295-304
Mendes, Jason; Parker, Dennis L (2011) Intrinsic detection of motion in segmented sequences. Magn Reson Med 65:1084-9

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