Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048258-05
Application #
2224325
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1992-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Chattopadhyay, Saurabh; Kessler, Sean P; Colucci, Juliana Almada et al. (2014) Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice. PLoS One 9:e87484
Chattopadhyay, Saurabh; Karan, Goutam; Sen, Indira et al. (2008) A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane. Biochemistry 47:8335-41
Kessler, Sean P; Senanayake, Preenie deS; Gaughan, Christina et al. (2007) Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. FASEB J 21:156-66
Chattopadhyay, Saurabh; Santhamma, Kizhakkekara R; Sengupta, Saubhik et al. (2005) Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem 280:33847-55
Kessler, Sean P; Hashimoto, Seiji; Senanayake, Preenie S et al. (2005) Nephron function in transgenic mice with selective vascular or tubular expression of Angiotensin-converting enzyme. J Am Soc Nephrol 16:3535-42
Kessler, Sean P; deS Senanayake, Preenie; Scheidemantel, Thomas S et al. (2003) Maintenance of normal blood pressure and renal functions are independent effects of angiotensin-converting enzyme. J Biol Chem 278:21105-12
Kessler, Sean P; Gomos, Janette B; Scheidemantel, Thomas S et al. (2002) The germinal isozyme of angiotensin-converting enzyme can substitute for the somatic isozyme in maintaining normal renal structure and functions. J Biol Chem 277:4271-6
Kessler, S P; Rowe, T M; Gomos, J B et al. (2000) Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme. J Biol Chem 275:26259-64
Sadhukhan, R; Sen, G C; Ramchandran, R et al. (1998) The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface. Proc Natl Acad Sci U S A 95:138-43
Ramaraj, P; Kessler, S P; Colmenares, C et al. (1998) Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme. J Clin Invest 102:371-8

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