Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL048540-05S1
Application #
2471511
Study Section
Metabolism Study Section (MET)
Project Start
1993-06-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817
Shechter, Ishaiahu; Dai, Peihua; Roseman, Mark A et al. (2003) Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells. J Lipid Res 44:1581-90
Shechter, Ishaiahu; Dai, Peihua; Huo, Liang et al. (2003) IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells. J Lipid Res 44:2169-80
Guan, Guimin; Dai, Peihua; Shechter, Ishaiahu (2003) cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. Arch Biochem Biophys 417:251-9
Tansey, T R; Shechter, I (2001) Squalene synthase: structure and regulation. Prog Nucleic Acid Res Mol Biol 65:157-95
Tansey, T R; Shechter, I (2000) Structure and regulation of mammalian squalene synthase. Biochim Biophys Acta 1529:49-62
Gupta, S D; Mehan, R S; Tansey, T R et al. (1999) Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. J Lipid Res 40:1572-84
Chen, H T; Mehan, R S; Gupta, S D et al. (1999) Involvement of farnesyl protein transferase (FPTase) in FcarepsilonRI-induced activation of RBL-2H3 mast cells. Arch Biochem Biophys 364:203-8
Guan, G; Dai, P; Shechter, I (1998) Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation. J Biol Chem 273:12526-35
Guan, G; Dai, P H; Osborne, T F et al. (1997) Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. J Biol Chem 272:10295-302
Memon, R A; Shechter, I; Moser, A H et al. (1997) Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters. J Lipid Res 38:1620-9

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