Embryonic Stem Cell Hematopoietic Development in Vitro

Keller, Gordon

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL048834-03
• Application #: 2224918
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1994-04-01
• Project End: 1999-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: National Jewish Health
• City: Denver
• State: CO
• Country: United States
• Zip Code: 80206

Publications

Adler, Eric D; Chen, Vincent C; Bystrup, Anne et al. (2010) The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction. FASEB J 24:1073-81

Irion, Stefan; Clarke, Raedun L; Luche, Herve et al. (2010) Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells. Development 137:2829-39

Cheng, Xin; Huber, Tara L; Chen, Vincent C et al. (2008) Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development 135:3447-58

Chen, Vincent C; Stull, Robert; Joo, Daniel et al. (2008) Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol 26:1169-78

Kattman, Steven J; Adler, Eric D; Keller, Gordon M (2007) Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends Cardiovasc Med 17:240-6

Kouskoff, Valerie; Lacaud, Georges; Schwantz, Staci et al. (2005) Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A 102:13170-5

Mohn, Deanna; Chen, Siming W; Dias, Dora Campos et al. (2003) Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Dev Dyn 226:446-59

Fehling, Hans Jorg; Lacaud, Georges; Kubo, Atsushi et al. (2003) Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development 130:4217-27

Lacaud, Georges; Gore, Lia; Kennedy, Marion et al. (2002) Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood 100:458-66

Yu, Tzong-Shiue; Moctezuma-Anaya, Miriam; Kubo, Atsushi et al. (2002) The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family. Mech Dev 116:187-92