Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL049192-08S1
Application #
6787986
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Program Officer
Sopko, George
Project Start
1995-04-01
Project End
2006-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
8
Fiscal Year
2003
Total Cost
$157,500
Indirect Cost

  Institution

Name
University of Rochester
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Xue, Chao; Sowden, Mark P; Berk, Bradford C (2018) Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases. Arterioscler Thromb Vasc Biol 38:986-993
Xue, Chao; Sowden, Mark; Berk, Bradford C (2017) Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation. Arterioscler Thromb Vasc Biol 37:1138-1146
Soe, Nwe Nwe; Sowden, Mark; Baskaran, Padmamalini et al. (2014) Acetylation of cyclophilin A is required for its secretion and vascular cell activation. Cardiovasc Res 101:444-53
Wang, Lian; Soe, Nwe Nwe; Sowden, Mark et al. (2014) Cyclophilin A is an important mediator of platelet function by regulating integrin ?IIb?3 bidirectional signalling. Thromb Haemost 111:873-82
Soe, Nwe Nwe; Sowden, Mark; Baskaran, Padmamalini et al. (2013) Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 33:2147-53
Nigro, Patrizia; Satoh, Kimio; O'Dell, Michael R et al. (2011) Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 208:53-66
Satoh, Kimio; Nigro, Patrizia; Zeidan, Asad et al. (2011) Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 31:1116-23
Satoh, Kimio; Nigro, Patrizia; Berk, Bradford C (2010) Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal 12:675-82
Satoh, Kimio; Shimokawa, Hiroaki; Berk, Bradford C (2010) Cyclophilin A: promising new target in cardiovascular therapy. Circ J 74:2249-56
Satoh, Kimio; Nigro, Patrizia; Matoba, Tetsuya et al. (2009) Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 15:649-56

Showing the most recent 10 out of 58 publications