Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050047-03
Application #
2226142
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1994-07-10
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Awwad, Hibah O; Iyer, Varsha; Rosenfeld, Jennifer L et al. (2007) Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Exp Cell Res 313:2586-96
Iyer, Varsha; Tran, Tuan M; Foster, Estrella et al. (2006) Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol 147:249-59
Millman, Ellen E; Rosenfeld, Jennifer L; Vaughan, David J et al. (2004) Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol 141:277-84
Moore, Robert H; Millman, Ellen E; Alpizar-Foster, Estrella et al. (2004) Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci 117:3107-17
Rosenfeld, J L; Moore, R H; Zimmer, K P et al. (2001) Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a. J Cell Sci 114:4499-508
Moore, R H; Tuffaha, A; Millman, E E et al. (1999) Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci 112 ( Pt 3):329-38
Moore, R H; Hall, H S; Rosenfeld, J L et al. (1999) Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation. Eur J Pharmacol 369:113-23
Morrison, K J; Moore, R H; Carsrud, N D et al. (1996) Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution. Mol Pharmacol 50:692-9
Moore, R H; Sadovnikoff, N; Hoffenberg, S et al. (1995) Ligand-stimulated beta 2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes. J Cell Sci 108 ( Pt 9):2983-91
Hoffenberg, S; Nikolova, L; Pan, J Y et al. (1995) Functional and structural interactions of the Rab5 D136N mutant with xanthine nucleotides. Biochem Biophys Res Commun 215:241-9