This application requests support for further data analysis and reporting work - - including for completion of work on original and expanded aims (hypothesis testing and exploratory analyses) - - in the international cooperative INTERMAP Study. INTERMAP is a basic epidemiologic investigation on the role of dietary factors (macroland micronutrients) and their urinary metabolites in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals. A particular focus - - within the context of this overall objective - - is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population strata, e.g., in the U.S. less educated African-Americans, Hispanics, Whites. INTERMAP aims to achieve a major advance on these important issues, based on its design: large sample size of 4,680 men and women ages 40-59 from 17 diverse population samples of varied ethnicity, SES, and dietary habits in 4 countries (China, Japan, U.K., U.S.). Cost effectiveness is assured by cost sharing by London centers and inclusion here of data analysis/reporting aims from 5 on-going NHLBI supported projects.
Specific aims i nvolve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, also individual amino acids, fatty acids, sugars, vitamins, Ca, Mg, Fe, P, Cu, Se, fiber, caffeine. Primary hypotheses being tested, with control for BMI, intake of alcohol, Na, K, age, sex, other confounders are: dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-related differences in multiple dietary factors; there is a direct relation to BP of dietary SFA, cholesterol, Keys score, starch; there is an inverse relation of PFAs and of P/S. Participants, randomly selected, provided 2 timed 24-hr urine collections for assessment of Na, K, creatinine, urea, Ca, Mg, macro- and microalbuminuria, amino acids, metabolites (NMR, HPLC, MS analyses), and four 24-hr dietary recalls. BP was measured 8 times (4 visits). The study is coordinated by two Coordinating Centers - - Northwestern University, Chicago and Imperial College, London. Urinary determinations have proceeded at Central Laboratories in Leuven and London. 24-hr dietary recalls have been converted into nutrients (75 currently, 83 by mid-2004) with use of 4 country-specific up-to-date, extensive, high-quality, standardized national data bases. Findings on relations of multiple dietary factors to BP are being used to estimate favorable impact on BP of multiple improvements in nutrition by populations. This, in turn, should aid in enhancing dietary recommendations for primary prevention o1 hypertension, and for shifting BP distributions downward to avoid excess risk associated with present unfavorable levels. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050490-12
Application #
7119477
Study Section
Special Emphasis Panel (ZRG1-HOP-J (02))
Program Officer
Loria, Catherine
Project Start
1995-07-01
Project End
2009-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
12
Fiscal Year
2006
Total Cost
$524,734
Indirect Cost
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Stamler, Jeremiah; Chan, Queenie; Daviglus, Martha L et al. (2018) Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study. Hypertension 71:631-637
Posma, Joram M; Garcia-Perez, Isabel; Ebbels, Timothy M D et al. (2018) Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data. J Proteome Res 17:1586-1595
Chekmeneva, Elena; Dos Santos Correia, Gonçalo; Gómez-Romero, María et al. (2018) Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine. J Proteome Res 17:3492-3502
Aljuraiban, Ghadeer S; Stamler, Jeremiah; Chan, Queenie et al. (2018) Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure. J Hypertens 36:2049-2058
Chan, Queenie; Loo, Ruey Leng; Ebbels, Timothy M D et al. (2017) Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview. Hypertens Res 40:336-345
Oude Griep, Linda M; Seferidi, Paraskevi; Stamler, Jeremiah et al. (2016) Relation of unprocessed, processed red meat and poultry consumption to blood pressure in East Asian and Western adults. J Hypertens 34:1721-9
Chan, Queenie; Stamler, Jeremiah; Griep, Linda M Oude et al. (2016) An Update on Nutrients and Blood Pressure. J Atheroscler Thromb 23:276-89
Aljuraiban, Ghadeer S; Griep, Linda M Oude; Griep, Linda M O et al. (2015) Total, insoluble and soluble dietary fibre intake in relation to blood pressure: the INTERMAP Study. Br J Nutr 114:1480-6
Elliott, Paul; Posma, Joram M; Chan, Queenie et al. (2015) Urinary metabolic signatures of human adiposity. Sci Transl Med 7:285ra62
Chan, Queenie; Stamler, Jeremiah; Elliott, Paul (2015) Dietary factors and higher blood pressure in African-Americans. Curr Hypertens Rep 17:10

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