Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL051445-06A1
Application #
6294315
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Thomas, John
Project Start
1993-12-01
Project End
2005-01-31
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
6
Fiscal Year
2001
Total Cost
$291,375
Indirect Cost
Name
St. Elizabeth's Medical Center of Boston
Department
Type
DUNS #
073797292
City
Boston
State
MA
Country
United States
Zip Code
01235
Lu, Yunzhe; Hanada, Toshihiko; Fujiwara, Yuko et al. (2016) Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood 128:93-103
Wieschhaus, Adam J; Le Breton, Guy C; Chishti, Athar H (2012) Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. J Biol Chem 287:41218-31
Yamada, Kaori H; Kozlowski, Dorothy A; Seidl, Stacey E et al. (2012) Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem 287:13182-93
Lorand, Laszlo; Murthy, S N Prasanna; Khan, Anwar A et al. (2011) Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan. Adv Enzymol Relat Areas Mol Biol 78:385-414
Liu, Fei; Khan, Anwar A; Chishti, Athar H et al. (2011) Atomic force microscopy demonstration of cytoskeleton instability in mouse erythrocytes with dematin-headpiece and ?-adducin deficiency. Scanning 33:426-36
Chen, Lin; Jiang, Zhenghui G; Khan, Anwar A et al. (2009) Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Protein Sci 18:629-36
Chen, Huiqing; Khan, Anwar A; Liu, Fei et al. (2007) Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia. J Biol Chem 282:4124-35
Kuchay, Shafi M; Kim, Nayoung; Grunz, Elizabeth A et al. (2007) Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets. Mol Cell Biol 27:6038-52
Kuchay, Shafi M; Chishti, Athar H (2007) Calpain-mediated regulation of platelet signaling pathways. Curr Opin Hematol 14:249-54
Marzia, Marilena; Chiusaroli, Riccardo; Neff, Lynn et al. (2006) Calpain is required for normal osteoclast function and is down-regulated by calcitonin. J Biol Chem 281:9745-54

Showing the most recent 10 out of 39 publications