Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051987-02
Application #
2229063
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1994-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Schlievert, Patrick M; Chuang-Smith, Olivia N; Peterson, Marnie L et al. (2010) Enterococcus faecalis endocarditis severity in rabbits is reduced by IgG Fabs interfering with aggregation substance. PLoS One 5:
Chuang-Smith, Olivia N; Wells, Carol L; Henry-Stanley, Michelle J et al. (2010) Acceleration of Enterococcus faecalis biofilm formation by aggregation substance expression in an ex vivo model of cardiac valve colonization. PLoS One 5:e15798
Chuang, Olivia N; Schlievert, Patrick M; Wells, Carol L et al. (2009) Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence. Infect Immun 77:539-48
Dunny, Gary M (2007) The peptide pheromone-inducible conjugation system of Enterococcus faecalis plasmid pCF10: cell-cell signalling, gene transfer, complexity and evolution. Philos Trans R Soc Lond B Biol Sci 362:1185-93
Kozlowicz, Briana K; Dworkin, Martin; Dunny, Gary M (2006) Pheromone-inducible conjugation in Enterococcus faecalis: a model for the evolution of biological complexity? Int J Med Microbiol 296:141-7
Hirt, Helmut; Manias, Dawn A; Bryan, Edward M et al. (2005) Characterization of the pheromone response of the Enterococcus faecalis conjugative plasmid pCF10: complete sequence and comparative analysis of the transcriptional and phenotypic responses of pCF10-containing cells to pheromone induction. J Bacteriol 187:1044-54
Kristich, Christopher J; Manias, Dawn A; Dunny, Gary M (2005) Development of a method for markerless genetic exchange in Enterococcus faecalis and its use in construction of a srtA mutant. Appl Environ Microbiol 71:5837-49
Chandler, Josephine R; Hirt, Helmut; Dunny, Gary M (2005) A paracrine peptide sex pheromone also acts as an autocrine signal to induce plasmid transfer and virulence factor expression in vivo. Proc Natl Acad Sci U S A 102:15617-22
Erlandsen, Stanley L; Kristich, Christopher J; Dunny, Gary M et al. (2004) High-resolution visualization of the microbial glycocalyx with low-voltage scanning electron microscopy: dependence on cationic dyes. J Histochem Cytochem 52:1427-35
Waters, Christopher M; Hirt, Helmut; McCormick, John K et al. (2004) An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid. Mol Microbiol 52:1159-71

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