Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054860-04
Application #
2873345
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-07-01
Project End
1999-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Lambert, Muriel W (2018) Spectrin and its interacting partners in nuclear structure and function. Exp Biol Med (Maywood) 243:507-524
Zhang, Pan; Sridharan, Deepa; Lambert, Muriel W (2016) Nuclear ? Spectrin Differentially Affects Monoubiquitinated Versus Non-Ubiquitinated FANCD2 Function After DNA Interstrand Cross-Link Damage. J Cell Biochem 117:671-83
Lambert, Muriel W (2016) Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability. Exp Biol Med (Maywood) 241:1621-38
Lambert, Muriel W (2015) Functional Significance of Nuclear ? Spectrin. J Cell Biochem 116:1816-30
Zhang, Pan; Herbig, Utz; Coffman, Frederick et al. (2013) Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage. Nucleic Acids Res 41:5321-40
Wang, Chuan; Lambert, Muriel W (2010) The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1. Biochemistry 49:5560-9
Zhang, Pan; Sridharan, Deepa; Lambert, Muriel W (2010) Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair. Biochemistry 49:5570-81
McMahon, Laura W; Zhang, Pan; Sridharan, Deepa M et al. (2009) Knockdown of alphaII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair. Biochem Biophys Res Commun 381:288-93
Lefferts, Joel A; Wang, Chuan; Sridharan, Deepa et al. (2009) The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG. Biochemistry 48:254-63
Kumaresan, Kandallu R; Sridharan, Deepa M; McMahon, Laura W et al. (2007) Deficiency in incisions produced by XPF at the site of a DNA interstrand cross-link in Fanconi anemia cells. Biochemistry 46:14359-68

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