Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL055002-06
Application #
2233534
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1990-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Trudeau Institute, Inc.
Department
Type
DUNS #
City
Saranac Lake
State
NY
Country
United States
Zip Code
12983
Swain, Steve D; Meissner, Nicole N; Siemsen, Dan W et al. (2012) Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness. Am J Respir Cell Mol Biol 46:290-8
Swain, Steve D; Meissner, Nicole; Han, Soo et al. (2011) Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens. Infect Immun 79:1905-14
Wiley, James A; Harmsen, Allen G (2008) Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. J Immunol 180:5613-24
Swain, Steve D; Han, Soo; Harmsen, Ann et al. (2007) Pulmonary hypertension can be a sequela of prior Pneumocystis pneumonia. Am J Pathol 171:790-9
Meissner, Nicole; Rutkowski, Melanie; Harmsen, Ann L et al. (2007) Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung. J Immunol 178:6604-15
Swain, Steve D; Meissner, Nicole N; Harmsen, Allen G (2006) CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol 168:466-75
Meissner, Nicole N; Swain, Steve; Tighe, Mike et al. (2005) Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174:5462-71
Meissner, Nicole N; Lund, Frances E; Han, Soo et al. (2005) CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175:8271-9
Swain, Steve D; Wright, Terry W; Degel, Peter M et al. (2004) Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice. Infect Immun 72:5722-32
An, Chun Li; Gigliotti, Francis; Harmsen, Allen G (2003) Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response. Infect Immun 71:2065-70

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