Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055291-01
Application #
2233848
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Horwitz, Lawrence D; Horwitz, Marcus A (2014) The exochelins of pathogenic mycobacteria: unique, highly potent, lipid- and water-soluble hexadentate iron chelators with multiple potential therapeutic uses. Antioxid Redox Signal 21:2246-61
Ambler, S Kelly; Hodges, Yvonne K; Jones, Gayle M et al. (2008) Prolonged administration of a dithiol antioxidant protects against ventricular remodeling due to ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol 295:H1303-H1310
Pahl, Paula M B; Reese, Sara M; Horwitz, Lawrence D (2007) A lipid-soluble iron chelator alters cell cycle regulatory protein binding in breast cancer cells compared to normal breast cells. J Exp Ther Oncol 6:193-200
Hodges, Yvonne K; Weinberger, Howard D; Stephens, Janet et al. (2006) Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron. Transl Res 148:63-71
Hodges, Yvonne K; Reese, Sara M; Pahl, Paula M B et al. (2005) Paradoxical effects of iron chelation on growth of vascular endothelial cells. J Cardiovasc Pharmacol 45:539-44
Pahl, Paula M B; Horwitz, Lawrence D (2005) Cell permeable iron chelators as potential cancer chemotherapeutic agents. Cancer Invest 23:683-91
Hodges, Yvonne K; Antholine, William E; Horwitz, Lawrence D (2004) Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins. Biochem Biophys Res Commun 315:595-8
Horwitz, L D; Sherman, N A (2001) Bucillamine prevents myocardial reperfusion injury. J Cardiovasc Pharmacol 38:859-67
Pahl, P M; Horwitz, M A; Horwitz, K B et al. (2001) Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res Treat 69:69-79
Rosenthal, E A; Bohlmeyer, T J; Monnet, E et al. (2001) An iron-binding exochelin prevents restenosis due to coronary artery balloon injury in a porcine model. Circulation 104:2222-7

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