Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055375-01
Application #
2233944
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Peterson, Eric C; Celikel, Reha; Gokulan, Kuppan et al. (2013) Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites. PLoS One 8:e82690
Zarpellon, Alessandro; Celikel, Reha; Roberts, James R et al. (2011) Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A 108:8628-33
Celikel, Reha; Peterson, Eric C; Owens, S Michael et al. (2009) Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine. Protein Sci 18:2336-45
Vasudevan, Sona; Celikel, Reha; Ruggeri, Zaverio M et al. (2004) A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure. Blood Cells Mol Dis 32:176-81
Corrons, Joan-Lluis Vives; Garcia, Estefania; Tusell, Joan J et al. (2003) Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia. Blood 102:353-6
Celikel, Reha; McClintock, Richard A; Roberts, James R et al. (2003) Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science 301:218-21
Varughese, Kottayil I; Celikel, Reha; Ruggeri, Zaverio M (2002) Structure and function of the von Willebrand factor A1 domain. Curr Protein Pept Sci 3:301-12
Sen, U; Vasudevan, S; Subbarao, G et al. (2001) Crystal structure of the von Willebrand factor modulator botrocetin. Biochemistry 40:345-52
Celikel, R; Madhusudan; Varughese, K I et al. (1997) Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain. Blood Cells Mol Dis 23:123-34
Balakrishnan, R; Ramasubbu, N; Varughese, K I et al. (1997) Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif. Proc Natl Acad Sci U S A 94:9620-5