Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL055934-02
Application #
2234551
Study Section
Special Emphasis Panel (ZHL1-CSR-N (S1))
Project Start
1995-09-30
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Kottom, Theodore J; Limper, Andrew H (2016) Evidence for a Pneumocystis carinii Flo8-like transcription factor: insights into organism adhesion. Med Microbiol Immunol 205:73-84
Kottom, Theodore J; Limper, Andrew H (2013) The Pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence. J Biol Chem 288:23893-902
Pupaibool, Jakrapun; Kottom, Theodore J; Bouchonville, Kelly et al. (2013) Characterization of the Pneumocystis carinii histone acetyltransferase chaperone proteins PcAsf1 and PcVps75. Infect Immun 81:2268-75
Villegas, Leah R; Kottom, Theodore J; Limper, Andrew H (2012) Chitinases in Pneumocystis carinii pneumonia. Med Microbiol Immunol 201:337-48
Carmona, Eva M; Kottom, Theodore J; Hebrink, Deanne M et al. (2012) Glycosphingolipids mediate pneumocystis cell wall ?-glucan activation of the IL-23/IL-17 axis in human dendritic cells. Am J Respir Cell Mol Biol 47:50-9
Kottom, Theodore J; Burgess, Joshua W; Limper, Andrew H (2011) Pneumocystis carinii interactions with lung epithelial cells and matrix proteins induce expression and activity of the PcSte20 kinase with subsequent phosphorylation of the downstream cell wall biosynthesis kinase PcCbk1. Infect Immun 79:4157-64
Kottom, Theodore J; Limper, Andrew H (2011) Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology. Yeast 28:707-19
Carmona, Eva M; Limper, Andrew H (2011) Update on the diagnosis and treatment of Pneumocystis pneumonia. Ther Adv Respir Dis 5:41-59
Kottom, Theodore J; Han, Junhong; Zhang, Zhiguo et al. (2011) Pneumocystis carinii expresses an active Rtt109 histone acetyltransferase. Am J Respir Cell Mol Biol 44:768-76
Carmona, Eva M; Lamont, Jeffrey D; Xue, Ailing et al. (2010) Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells. Respir Res 11:95

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