by a second class of genes associated with sensory cilia, that are Foxj1-independent.
Specific Aims to test this hypothesis will address: (1) Foxj1-dependent genes to characterize mechanisms of Foxj1 activation for motile assembly and function, and (2) Foxj1-independent sensory cilia genes to investigate their roles in motile cilia assembly and function. Completion of the proposed studies will provide information related to the regulation of mammalian ciliogenesis and open new avenues for examining the evolving role of sensory proteins in airway epithelial cells. Investigation of functions of the ciliated cell will provide new insights into development, differentiation and pathogenesis of airways diseases. Project Description Page 6
| Rieger, Megan E; Zhou, Beiyun; Solomon, Nicola et al. (2016) p300/?-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem 291:6569-82 |
| Pan, Jie-Hong; Adair-Kirk, Tracy L; Patel, Anand C et al. (2014) Myb permits multilineage airway epithelial cell differentiation. Stem Cells 32:3245-56 |
| Horani, Amjad; Brody, Steven L; Ferkol, Thomas W (2014) Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res 75:158-64 |
| Horani, Amjad; Brody, Steven L; Ferkol, Thomas W et al. (2013) CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia. PLoS One 8:e72299 |
| Vladar, Eszter K; Brody, Steven L (2013) Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells. Methods Enzymol 525:285-309 |
| Horani, Amjad; Nath, Aditya; Wasserman, Mollie G et al. (2013) Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol 49:341-7 |
| Horani, Amjad; Ferkol, Thomas W; Shoseyov, David et al. (2013) LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One 8:e59436 |
| Jain, Raksha; Ray, Jennifer M; Pan, Jie-hong et al. (2012) Sex hormone-dependent regulation of cilia beat frequency in airway epithelium. Am J Respir Cell Mol Biol 46:446-53 |
| Jain, Raksha; Javidan-Nejad, Cylen; Alexander-Brett, Jennifer et al. (2012) Sensory functions of motile cilia and implication for bronchiectasis. Front Biosci (Schol Ed) 4:1088-98 |
| Horani, Amjad; Druley, Todd E; Zariwala, Maimoona A et al. (2012) Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet 91:685-93 |
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