Abstract

The focus of this application is to elucidate the functional role and regulation of TTF-1 in lung development.
Aim 1 is to determine the role of TTF-1 in the regulation of lung morphogenesis by isolating and characterizing putative TTF-1 target genes.
Aim 2 is to determine the role of TTF-1 in regulating differentiation-specific genes.
Aim 3 is to identify higher order combinatorial protein-protein interactions as possible regulatory means for the cell type and tissue specificity of TTF-1 activity.
Aim 4 is to determine the cis-and trans-acting factors which regulate TTF-1 during lung morphogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL056590-02
Application #
2460207
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Rieger, Megan E; Zhou, Beiyun; Solomon, Nicola et al. (2016) p300/?-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem 291:6569-82
Flodby, Per; Kim, Yong Ho; Beard, LaMonta L et al. (2016) Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol 55:395-406
Xing, Yiming; Wang, Runming; Li, Changgong et al. (2015) PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway. Dev Biol 408:56-65
Li, Changgong; Li, Min; Li, Sha et al. (2015) Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells 33:999-1012
Li, Guanglei; Flodby, Per; Luo, Jiao et al. (2014) Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol 51:210-22
Kage, Hidenori; Flodby, Per; Gao, Danping et al. (2014) Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol 307:L524-36
Zhou, Beiyun; Liu, Yixin; Kahn, Michael et al. (2012) Interactions between ?-catenin and transforming growth factor-? signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem 287:7026-38
DeMaio, Lucas; Buckley, Stephen T; Krishnaveni, Manda S et al. (2012) Ligand-independent transforming growth factor-? type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol 226:633-44
Zhong, Qian; Zhou, Beiyun; Ann, David K et al. (2011) Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol 45:498-509
Minoo, Parviz; Li, Changgong (2010) Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease. Int J Biochem Cell Biol 42:809-12

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