Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL062881-09
Application #
6527358
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Program Officer
Reinlib, Leslie
Project Start
1995-08-01
Project End
2003-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
9
Fiscal Year
2002
Total Cost
$267,152
Indirect Cost

  Institution

Name
Washington State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164

  Publications

Methawasin, Mei; Granzier, Henk (2018) Softening the Stressed Giant Titin in Diabetes Mellitus. Circ Res 123:315-317
Tonino, Paola; Kiss, Balazs; Strom, Josh et al. (2017) The giant protein titin regulates the length of the striated muscle thick filament. Nat Commun 8:1041
Methawasin, Mei; Granzier, Henk (2017) Response by Methawasin and Granzier to Letter Regarding Article, ""Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Frac Circulation 135:e681-e682
Kellermayer, Dalma; Smith 3rd, John E; Granzier, Henk (2017) Novex-3, the tiny titin of muscle. Biophys Rev 9:201-206
Hinze, Florian; Dieterich, Christoph; Radke, Michael H et al. (2016) Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy. J Mol Med (Berl) 94:1349-1358
Kolb, Justin; Li, Frank; Methawasin, Mei et al. (2016) Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin. J Mol Cell Cardiol 97:286-94
Bull, Mathew; Methawasin, Mei; Strom, Joshua et al. (2016) Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (Ttn?IAjxn). Circ Res 119:764-72
Methawasin, Mei; Strom, Joshua G; Slater, Rebecca E et al. (2016) Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction. Circulation 134:1085-1099
Pappas, Christopher T; Mayfield, Rachel M; Henderson, Christine et al. (2015) Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A 112:13573-8
Hutchinson, Kirk R; Saripalli, Chandra; Chung, Charles S et al. (2015) Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. J Mol Cell Cardiol 79:104-14

Showing the most recent 10 out of 113 publications