Results from the NIMH Collaborative Depression Study (CDS) have clearly show that affective illness is a lifetime disorder and the long-term observation will be necessary to adequately characterize it. Follow-up so far shows high rates of recovery, recurrence, changes in inter-episode psychosocial functioning, comorbid alcoholism, minor affective syndromes, mortality and suicide. Recoveries are likely even after lengthy periods of illness, the distribution of episode length is relatively constant and unimpaired psychosocial functioning appears to require a complete absence of symptoms. It is essential that this follow-up continue, especially as the probands enter their sixth and seventh decades of life. This application seeks to extend the prospective annual follow-up of the CDS proband sample to at least 22 years for all subjects. The general aim in doing this is to describe the long-term course of the affective disorders.
The specific aims are to collect data that will describe more fully: 1) the cumulative probability of recovery and recurrence, and the changes in polarity, severity, and episode and cycle lengths; 2) the predictors of long-term course and diagnostic change; 3) the eventual level of psychosocial functioning, physical health likelihood of suicide and mental health services utilization; 4) the influence of naturalistically applied treatments as a mediating variable; 5) the course and outcomes of subsyndromal states of affective disorders; and 6) the long-term inter-relationships of the affective disorders and other chronic and recurrent disorders such as alcohol and drug us disorders.
| Leon, Andrew C; Fiedorowicz, Jess G; Solomon, David A et al. (2014) Risk of suicidal behavior with antidepressants in bipolar and unipolar disorders. J Clin Psychiatry 75:720-7 |
| Cobb, Bryan S; Coryell, William H; Cavanaugh, Joseph et al. (2014) Seasonal variation of depressive symptoms in unipolar major depressive disorder. Compr Psychiatry 55:1891-9 |
| Solomon, David A; Fiedorowicz, Jess G; Leon, Andrew C et al. (2013) Recovery from multiple episodes of bipolar I depression. J Clin Psychiatry 74:e205-11 |
| Akhter, Ahmed; Fiedorowicz, Jess G; Zhang, Tao et al. (2013) Seasonal variation of manic and depressive symptoms in bipolar disorder. Bipolar Disord 15:377-84 |
| Coryell, William; Fiedorowicz, Jess; Leon, Andrew C et al. (2013) Age of onset and the prospectively observed course of illness in bipolar disorder. J Affect Disord 146:34-8 |
| Shankman, Stewart A; Campbell, Miranda L; Klein, Daniel N et al. (2013) Dysfunctional attitudes as a moderator of pharmacotherapy and psychotherapy for chronic depression. J Psychiatr Res 47:113-21 |
| Fiedorowicz, Jess G; Endicott, Jean; Solomon, David A et al. (2012) Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression. Bipolar Disord 14:664-71 |
| Coryell, William; Fiedorowicz, Jess G; Solomon, David et al. (2012) Effects of anxiety on the long-term course of depressive disorders. Br J Psychiatry 200:210-5 |
| Dunlop, Boadie W; Holland, Peter; Bao, Weihang et al. (2012) Recovery and subsequent recurrence in patients with recurrent major depressive disorder. J Psychiatr Res 46:708-15 |
| Judd, Lewis L; Schettler, Pamela J; Akiskal, Hagop et al. (2012) Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes. J Affect Disord 138:440-8 |
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