We live in an environment that often signals the likelihood of the occurrence of some future event. If stimuli are to signal future events they must be remembered. Because neuronal circuits that mediate such memories are often poorly characterized, the mnemonic processes that are necessary for past stimuli to influence future behavior have not been subjected to systematic investigation at the neuronal level. We have developed a preparation in which such studies are possible. Specifically, we will study neuronal mechanisms that mediate a preparatory state. This state is induced by signaling stimuli, and functions to improve an animal's responsiveness to subsequent stimuli (i.e., stimuli that are delivered after the signaling stimulus is no longer present). Our studies will center on the control of biting responses. We propose to test the hypothesis that the preparatory state that we study is not a single indivisible unit. Instead it consists of multiple components that can be independently controlled. We suggest that higher order neurons (e.g., CPR) activate several modulatory neurons that in turn control different components of the preparatory state. Furthermore, we suggest that the full complement of behavioral effects (including the persistence of the preparatory state) may not emerge from a simple summation of different effects. Instead behavioral effects emerge from complex interactions between different components. Preparatory states play a critical role in assuring effective actions in complex environments. Impairment in the induction or persistence of such a state is likely to give rise to serious behavioral pathologies that may manifest themselves in such disorders as depression and adult attention deficit syndrome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH035564-34
Application #
7194980
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Vicentic, Aleksandra
Project Start
1981-05-01
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
34
Fiscal Year
2007
Total Cost
$359,780
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Vilim, Ferdinand S; Sasaki, Kosei; Rybak, Jurgen et al. (2010) Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors. J Neurosci 30:131-47
Jing, Jian; Gillette, Rhanor; Weiss, Klaudiusz R (2009) Evolving concepts of arousal: insights from simple model systems. Rev Neurosci 20:405-27
Friedman, Allyson K; Zhurov, Yuriy; Ludwar, Bjoern Ch et al. (2009) Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states. J Neurophysiol 102:3711-27
Sasaki, Kosei; Brezina, Vladimir; Weiss, Klaudiusz R et al. (2009) Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition. J Neurosci 29:11732-44
Sasaki, Kosei; Jing, Jian; Due, Michael R et al. (2008) An input-representing interneuron regulates spike timing and thereby phase switching in a motor network. J Neurosci 28:1916-28
Sasaki, Kosei; Due, Michael R; Jing, Jian et al. (2007) Feeding CPG in Aplysia directly controls two distinct outputs of a compartmentalized interneuron that functions as a CPG element. J Neurophysiol 98:3796-801
Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R et al. (2007) Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides. J Neurophysiol 97:481-91
Jing, Jian; Vilim, Ferdinand S; Horn, Charles C et al. (2007) From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y. J Neurosci 27:3490-502
Hurwitz, Itay; Susswein, Abraham J; Weiss, Klaudiusz R (2005) Transforming tonic firing into a rhythmic output in the Aplysia feeding system: presynaptic inhibition of a command-like neuron by a CpG element. J Neurophysiol 93:829-42
Proekt, Alex; Vilim, Ferdinand S; Alexeeva, Vera et al. (2005) Identification of a new neuropeptide precursor reveals a novel source of extrinsic modulation in the feeding system of Aplysia. J Neurosci 25:9637-48

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