Abstract

The goals of this longitudinal study are to identify the nature and size of risk factors for depression in childhood. Approximately 180 offspring of parents with mild or severe unipolar depression and approximately 105 offspring of parents without psychiatric illness are examined at the start of the study and again two years later. The psychiatric and social/adaptive status of the children is assessed at both points.
Research aims i nclude identifying genetic and environmental risk factors associated with the onset of depressive disorders in children, identifying preclinical signs of depression, and determining the impact of parental depression on children. Most children are between 6 and 17 years of age at the time of initial assessment; some adolescents over 18 years are included.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH036197-05
Application #
3375812
Study Section
(PCBA)
Project Start
1981-09-01
Project End
1986-12-31
Budget Start
1985-09-01
Budget End
1986-12-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code

  Publications

Tenke, Craig E; Kayser, Jürgen; Alvarenga, Jorge E et al. (2018) Temporal stability of posterior EEG alpha over twelve years. Clin Neurophysiol 129:1410-1417
Bansal, Ravi; Peterson, Bradley S (2018) Cluster-level statistical inference in fMRI datasets: The unexpected behavior of random fields in high dimensions. Magn Reson Imaging 49:101-115
Cha, Jiook; Guffanti, Guia; Gingrich, Jay et al. (2018) Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression. Cereb Cortex 28:1911-1921
Weissman, Myrna M; Talati, Ardesheer; Hao, Xuejun et al. (2018) Risks for Major Depression: Searching for Stable Traits. Biol Psychiatry 83:7-8
Hao, Xuejun; Talati, Ardesheer; Shankman, Stewart A et al. (2017) Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years. Biol Psychiatry Cogn Neurosci Neuroimaging 2:619-625
Anderson, Micheline R; Miller, Lisa; Wickramaratne, Priya et al. (2017) Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression. Spiritual Clin Pract (Wash D C ) 4:43-63
Kayser, Jürgen; Tenke, Craig E; Abraham, Karen S et al. (2017) Motivated attention and family risk for depression: Neuronal generator patterns at scalp elicited by lateralized aversive pictures reveal blunted emotional responsivity. Neuroimage Clin 14:692-707
Talati, Ardesheer; Wickramaratne, Priya J; Wesselhoeft, Rikke et al. (2017) Prenatal tobacco exposure, birthweight, and offspring psychopathology. Psychiatry Res 252:346-352
Bansal, Ravi; Hao, Xuejun; Peterson, Bradley S (2017) Segmenting and validating brain tissue definitions in the presence of varying tissue contrast. Magn Reson Imaging 35:98-116
Svob, Connie; Liu, Jie; Wickramaratne, Priya et al. (2017) Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. Spiritual Clin Pract (Wash D C ) 4:32-42

Showing the most recent 10 out of 178 publications