Abstract

The long-term goal of the proposed research is to analyze the neural mechanisms controlling the expression of arousal in complex behavior. The research will utilize food-induced arousal in Aplysia as a model of arousal in higher animals.
The specific aim of the present project is to explore a novel general hypothesis that behavioral arousal is an expression of the action of two types of modulation, both of which serve to improve the efficiency of biting. One type of modulation is extrinsic to the basic sensory-motor circuits that drive behavior. Extrinsic modulation is subject to sensory controls that reflect motivational states. A second type of modulation involves factors intrinsic to the mediating sensory-motor circuits. This type of intrinsic modulation may not be subject to motivational controls, but could serve to fine tune the sensory-motor system so that it can better meet the specific demands of muscle movements. It is not difficult to imagine that malfunction of widespread modulatory systems would have profound effects on behavior and it remains as a distinct possibility that an understanding of these systems in an animal such as Aplysia will contribute to the amelioration of disorders of affect, cognition, and movement.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH036730-04
Application #
3375911
Study Section
(BPNB)
Project Start
1982-05-01
Project End
1988-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Livnat, Itamar; Tai, Hua-Chia; Jansson, Erik T et al. (2016) A d-Amino Acid-Containing Neuropeptide Discovery Funnel. Anal Chem 88:11868-11876
Jing, Jian; Vilim, Ferdinand S; Cropper, Elizabeth C et al. (2008) Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion. J Neurosci 28:12349-61
Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R et al. (2007) Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides. J Neurophysiol 97:481-91
Wu, Jin-sheng; Due, Michael R; Sasaki, Kosei et al. (2007) State dependence of spike timing and neuronal function in a motor pattern generating network. J Neurosci 27:10818-31
Proekt, Alex; Jing, Jian; Weiss, Klaudiusz R (2007) Multiple contributions of an input-representing neuron to the dynamics of the aplysia feeding network. J Neurophysiol 97:3046-56
Koh, Hae-Young; Weiss, Klaudiusz R (2007) Activity-dependent peptidergic modulation of the plateau-generating neuron B64 in the feeding network of Aplysia. J Neurophysiol 97:1862-7
Orekhova, Irina V; Alexeeva, Vera; Church, Paul J et al. (2003) Multiple presynaptic and postsynaptic sites of inhibitory modulation by myomodulin at ARC neuromuscular junctions of Aplysia. J Neurophysiol 89:1488-502
McDearmid, Jonathan R; Brezina, Vladimir; Weiss, Klaudiusz R (2002) AMRP peptides modulate a novel K(+) current in pleural sensory neurons of Aplysia. J Neurophysiol 88:323-32
Orekhova, I V; Jing, J; Brezina, V et al. (2001) Sonometric measurements of motor-neuron-evoked movements of an internal feeding structure (the radula) in Aplysia. J Neurophysiol 86:1057-61
Karhunen, T; Vilim, F S; Alexeeva, V et al. (2001) Targeting of peptidergic vesicles in cotransmitting terminals. J Neurosci 21:RC127

Showing the most recent 10 out of 60 publications