Previous research has shown that cognitive psychotherapy (CT) reduces or eliminates symptoms in many outpatients with nonpsychotic, nonbiopolar major depression. One followup study suggests that prophylaxis ensues in 56% of those treated with CT in the year following treatment. However, not all patients respond. Roughly 60% attain a complete clinical remission by end of treatment. No consistent predictors of acute or prophylactic response to CT are known. Eighty male and female outpatients (aged 21-60 years) with nonpsychotic, nonbipolar major depression will be evaluated by SADS-L interviews, Research Diagnostic Criteria, symptom severity, history of illness, and selected cognitive measures, as well as by two consecutive nights of sleep EEG prior to treatment with 10 weeks (20 sessions) of cognitive therapy. Two groups (forty each) will be formed based on pretreatment REM latency (RLs) values. The main predictions to be tested are: those with low RLs (less than 60 minutes) will respond less well acutely and prophylactically than will those with RLs of 60 minutes or greater. Whether the acute or prophylactic response to CT can be predicted by history of illness (e.g., length of episode, length of illness, etc.) or cognitive measures (e.g., dysfunctional attitudes, self-control scale scores, etc.) will also be evaluated. Finally, whether symptomatic response is associated with cognitive or sleep EEG changes will be assessed. To date, two therapists have been trained to competency in CT, 13 cases have been treated (including training cases), a clinical/laboratory system has been established to ensure that therapists, evaluators, and laboratory personnel are blind to each other's findings, and patient follow up system is in place to track patients after CT is completed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH038238-03
Application #
3376543
Study Section
(TDAC)
Project Start
1983-09-01
Project End
1988-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Taylor, Daniel J; Walters, Heather M; Vittengl, Jeffrey R et al. (2010) Which depressive symptoms remain after response to cognitive therapy of depression and predict relapse and recurrence? J Affect Disord 123:181-7
Vittengl, Jeffrey R; Clark, Lee Anna; Jarrett, Robin B (2010) Moderators of continuation phase cognitive therapy's effects on relapse, recurrence, remission, and recovery from depression. Behav Res Ther 48:449-58
Vittengl, Jeffrey R; Clark, Lee Anna; Jarrett, Robin B (2009) Deterioration in psychosocial functioning predicts relapse/recurrence after cognitive therapy for depression. J Affect Disord 112:135-43
Smits, Jasper A J; Minhajuddin, Abu; Jarrett, Robin B (2009) Cognitive therapy for depressed adults with comorbid social phobia. J Affect Disord 114:271-8
Vittengl, Jeffrey R; Clark, Lee Anna; Jarrett, Robin B (2009) Continuation-phase cognitive therapy's effects on remission and recovery from depression. J Consult Clin Psychol 77:367-71
Jarrett, Robin B; Vittengl, Jeffrey R; Clark, Lee Anna (2008) How much cognitive therapy, for which patients, will prevent depressive relapse? J Affect Disord 111:185-92
Kashner, T Michael; Henley, Steven S; Golden, Richard M et al. (2007) Assessing the preventive effects of cognitive therapy following relief of depression: A methodological innovation. J Affect Disord 104:251-61
Jarrett, Robin B; Vittengl, Jeffrey R; Doyle, Kimberly et al. (2007) Changes in cognitive content during and following cognitive therapy for recurrent depression: substantial and enduring, but not predictive of change in depressive symptoms. J Consult Clin Psychol 75:432-46
Vittengl, Jeffrey R; Clark, Lee Anna; Kraft, Dolores et al. (2005) Multiple measures, methods, and moments: a factor-analytic investigation of change in depressive symptoms during acute-phase cognitive therapy for depression. Psychol Med 35:693-704
Vittengl, Jeffrey R; Clark, Lee Anna; Jarrett, Robin B (2005) Validity of sudden gains in acute phase treatment of depression. J Consult Clin Psychol 73:173-82

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