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Clark, Alia H; McCorvy, John D; Conley, Jason M et al. (2012) Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine Dýýý receptor-selective full agonist ligand. Bioorg Med Chem 20:6366-74
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Chemel, Benjamin R; Bonner, Lisa A; Watts, Val J et al. (2012) Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. Mol Pharmacol 81:729-38
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Cueva, Juan Pablo; Chemel, Benjamin R; Juncosa Jr, Jose I et al. (2012) Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. Eur J Med Chem 48:97-107
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Cueva, Juan Pablo; Gallardo-Godoy, Alejandra; Juncosa, Jose I et al. (2011) Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7ýý-, 7ýý-, 8ýý-, and 8ýý-methyl substituted dihydrexidine analogues. J Med Chem 54:5508-21
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Clark, Alia H; McCorvy, John D; Watts, Val J et al. (2011) Assessment of dopamine Dýýý receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorg Med Chem 19:5420-31
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Bonner, Lisa A; Laban, Uros; Chemel, Benjamin R et al. (2011) Mapping the catechol binding site in dopamine D? receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. ChemMedChem 6:1024-40
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Bonner, Lisa A; Chemel, Benjamin R; Watts, Val J et al. (2010) Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorg Med Chem 18:6763-70
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Przybyla, Julie A; Cueva, Juan P; Chemel, Benjamin R et al. (2009) Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. Eur Neuropsychopharmacol 19:138-46
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Cueva, Juan Pablo; Giorgioni, Gianfabio; Grubbs, Russell A et al. (2006) trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. J Med Chem 49:6848-57
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Ryman-Rasmussen, Jessica P; Nichols, David E; Mailman, Richard B (2005) Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. Mol Pharmacol 68:1039-48
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Showing the most recent 10 out of 48 publications
