Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH047346-05
Application #
2247564
Study Section
Life Course and Prevention Research Review Committee (LCR)
Project Start
1992-09-30
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Zubenko, George S; Hughes 3rd, Hugh B; Jordan, Rick M et al. (2014) Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 165B:457-66
Zubenko, George S; Hughes 3rd, Hugh B (2012) No evidence of non-homologous insertions in mouse model of MDD created by replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence. Am J Med Genet B Neuropsychiatr Genet 159B:1-4
Zubenko, George S; Hughes 3rd, Hugh B (2011) Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 156B:517-31
Zubenko, George S; Hughes 3rd, Hugh B (2010) Effects of the A(-115)G variant on CREB1 promoter activity in two brain cell lines: Interactions with gonadal steroids. Am J Med Genet B Neuropsychiatr Genet 153B:1365-72
Maher, Brion S; Hughes 3rd, Hugh B; Zubenko, Wendy N et al. (2010) Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation of sex-specific effect. Am J Med Genet B Neuropsychiatr Genet 153B:10-6
Zubenko, George S; Jones, Michelle L; Estevez, Annette O et al. (2009) Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments? Am J Med Genet B Neuropsychiatr Genet 150B:12-23
Zubenko, G S; Hughes 3rd, H B (2009) Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress. Mol Psychiatry 14:390-7
Zubenko, George S; Hughes 3rd, Hugh B (2008) Effects of the G(-656)A variant on CREB1 promoter activity in a glial cell line: interactions with gonadal steroids and stress. Am J Med Genet B Neuropsychiatr Genet 147B:579-85
Zubenko, G S; Stiffler, S; Stabler, S et al. (1994) Association of the apolipoprotein E epsilon 4 allele with clinical subtypes of autopsy-confirmed Alzheimer's disease. Am J Med Genet 54:199-205